Dieses Buch bietet neue Einblicke in die Pathogenese der Atherosklerose. Die Kapitel befassen sich mit den Risikofaktoren für Atherosklerose, den Auswirkungen von Wachstum und Alterung auf die Gefäßarchitektur und der entscheidenden Rolle, die das Mikrogefäßsystem bei der Entstehung von Atherosklerose spielt. Eine mikrovaskuläre Dysfunktion würde erklären, warum die bekannten Risikofaktoren das Risiko für den Einzelnen tatsächlich erhöhen. Dieser Pathomechanismus würde nicht nur für die obstruktive Atherombildung gelten, sondern auch für die aneurysmatische Dilatation sowie für die Dissektion der Aorta und der peripheren Arterien. Durch diese Brille betrachtet, ergeben sich neue präventive und therapeutische Möglichkeiten. In Atherosclerosis Pathogenesis and Microvascular Dysfunction wird ein einheitlicher Mechanismus für die Entstehung von Atherosklerose vorgeschlagen und es werden potenzielle präventive und therapeutische Möglichkeiten auf der Grundlage dieses Konzepts beschrieben. Das Buch stellt daher eine zeitgemäße und wertvolle Ressource für Ärzte der Inneren Medizin, Kardiologie, Angiologie, Herz- und Gefäßchirurgen, Pathologen, Forscher, Auszubildende und Studenten dar.

This book reviews the surgical management of patients with aortic disease, revealing many options open to cardiovascular specialists in this often controversial area of management. It reviews each controversy and provides clinical information for cardiac surgery, and discusses the spectrum of disorders and their management. With the knowledge base in this discipline changing rapidly, Controversies in Aortic Dissection and Aneurysmal Disease meets an important requirement to consolidate the wide-ranging information on which clinicians must base their practice. It is directed towards surgeons, physicians, and healthcare workers involved in the care of patients requiring cardiac, cardiothoracic and cardiovascular surgery. This book will be an essential resource for these professionals looking to accelerate the translation of basic research findings into clinical study and practice.

As dogmas in stem cell research are losing their impact and recent findings regarding the use and cultivation of stem cells and tissue transplantation have opened up new therapeutic avenues, this Ernst Schering Research Foundation Workshop was initiated to highlight current and future approaches in this field. The only stem cells that have been used clinically for a long time is the hematopoietic stem cell as a source for bone marrow transplantation. Recent findings now indicate that hematopoietic stem cells, under certain conditions, are able to differentiate into endothelial, neural or muscle cells, providing exciting new therapeutic possibilities. They represent a future source for tissue engineering replacing defective cells or tissues and allowing diseased organs to regain their functions. Both reconstitution techniques are paving the way for the development of new therapeutic strategies, giving hope of being able to cure and not only treat patients.

This book provides new perspectives on the pathogenesis of atherosclerosis. Chapters cover atherosclerosis risk factors, the effect of growth and aging on vascular architecture, and the crucial role the microvasculature plays in atherosclerosis development. Microvascular dysfunction would explain why the well-known risk factors actually put individuals at higher risk. This pathomechanism would also hold true not only for obstructive atheroma formation but also for aneurysmal dilatation as well as for aortic and peripheral artery dissection. When seen through this lens, novel preventive and therapeutic opportunities can be envisioned. Atherosclerosis Pathogenesis and Microvascular Dysfunction proposes a single unifying mechanism of atherosclerosis development and describes potential preventative and therapeutic avenues based on this concept. It therefore represents a timely and valuable resource for internal medicine, cardiology, angiology cardiovascular surgeons, pathology clinicians, researchers, trainees, and students.

In this book the authors review the surgical management of patients with aortic disease. This often controversial area of management reveals many options open to cardiovascular specialist. This reference reviews each controversy and provides practical answers to the cardiac surgeon and will help them reveal the spectrum of disorders and their management.

Fibrinkleber werden seit Jahrzehnten erfolgreich in der Wundheilung und in der Nervenklebung angewandt und finden einen breiten Einsatz in allen Gebieten der Chirurgie. Es ist Anliegen der vorliegenden Monographie, das Indikationsspektrum fur den Einsatz des Fibrinklebers insbesondere in der Thorax- und Kardiovaskularchirurgie zu beleuchten.