Les amines heterocycliques (AH) sont des cancerogenes alimentaires produits lors de la cuisson des viandes et des poissons. Peu de travaux ont ete menes in vivo sur la modulation de leur genotoxicite par l''aliment. Nous avons montre que le chou de Bruxelles, l''inuline et un lait fermente reduisent l''effet genotoxique d''une AH modele, l''IQ, dans les colonocytes et les hepatocytes de rats a flore humaine. L''effet du chou de Bruxelles est correle a l''augmentation de l''activite d''une enzyme de detoxication de l''IQ tandis que celui de l''inuline entraine un bouleversement du mmicrobiote intestinal, en particulier d''une diminution de l''activite -glucuronidase. Nous avons donc construit un mutant d''Escherichia coli isogenique pour le gene codant pour la - glucuronidase et monoassocie des rats sans germe, soit avec la souche sauvage soit avec son mutant isogenique, et demontre le role clef de cette enzyme dans la genotoxicite de l''IQ. Enfin, nous avons incube des flores et des bacteries fecales humaines avec de l''IQ et nous n''avons detecte qu''un seul metabolite bacterien, la 7-OH-IQ qui serait un metabolite de detoxication.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ La Foi Justifiee De Tout Reproche De Contradiction Avec La Raison... Avec Une Analyse De La Foi Jean-Francois de La Marche, Humblot Humblot, 1766

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ Le Deisme Refute Par Lui-meme Ou Examen Des Principes D'incredulite Repandus Dans Les Divers Ouvrages De M. Rousseau, En Forme De Lettres. Par M. Bergier... Nicolas Bergier, Humblot Chez Humblot, 1768 Literary Criticism; European; French; Literary Criticism / European / French