The Executive Guide to Managing Disputes not only explains why litigation is so costly, but also how to manage disputes sensibly to avoid unnecessary litigation, reduce costs, and improve results. The book shows how ADR (i.e., Alternative Dispute Resolution) can short-cut disputes, and how to use often inexpensive dispute management programs to contain costs and achieve favorable outcomes.

Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.

It is our pleasure to present this special volume on tissue engineering in the series Advances in Biochemical Engineering and Biotechnology. Thisvolume re?ects the emergence of tissue engineering as a core discipline of modern biomedical engineering, and recognizes the growing synergies between the technological developments in biotechnology and biomedicine. Along this vein, the focusof thisvolume istoprovide abiotechnology driven perspective on cell engineering fundamentals while highlighting their signi?cance in p- ducing functional tissues. Our aim is to present an overview of the state of the art of a selection of these technologies, punctuated with current applications in the research and development of cell-based therapies for human disease. To prepare this volume, we have solicited contributions from leaders and experts in their respective ?elds, ranging from biomaterials and bioreactors to gene delivery and metabolic engineering. Particular emphasis was placed on including reviews that discuss various aspects of the biochemical p- cesses underlying cell function, such as signaling, growth, differentiation, and communication. The reviews of research topics cover two main areas: cel- lar and non-cellular components and assembly; evaluation and optimization of tissue function; and integrated reactor or implant system development for research and clinical applications. Many of the reviews illustrate how bioche- cal engineering methods are used to produce and characterize novel materials (e. g. genetically engineered natural polymers, synthetic scaffolds with ce- type speci?c attachment sites or inductive factors), whose unique properties enable increased levels of control over tissue development and architecture.

An eminent child psychiatrist provides an insider's, whistle-blowing perspective on the promotion of a diagnostic entity that does not exist. Your Child Does Not Have Bipolar Disorder: How Bad Science and Good Public Relations Created the Diagnosis examines this diagnostic fad through a variety of lenses. Author Stuart L. Kaplan, MD, draws heavily on his forty years of experience as a clinician, researcher, and professor of child psychiatry to make the argument that bipolar disorder in children and adolescents is incorrectly diagnosed and incorrectly treated. As Dr. Kaplan explains, the dramatic rise in this particular diagnosis is not based on scientific evidence, nor does it reflect any new discovery or insight about the etiology or treatment of the disorder. In fact, the opposite is the case: the scientific evidence against the existence of child bipolar disorder is so strong that it is difficult to imagine how it has gained the endorsement of anyone in the scientific community. Your Child Does Not Have Bipolar Disorder: How Bad Science and Good Public Relations Created the Diagnosis explains to parents and professionals the faulty reasoning and bad science behind the misdiagnosis of childhood bipolar disorder. Dr. Kaplan critiques the National Institute of Mental Health, academic child psychiatry, the pharmaceutical industry, and the media for their respective roles in advocating this diagnosis. He describes very clearly what the children and adolescents actually do have, explains how it should be treated, and provides real-life clinical scenarios and approaches to treatment that work. Arresting case histories A reference section

In her latest book, Dr. Louise Kaplan, author of the groundbreaking "Female Perversions, "explores the fetishism strategy, a psychological defense that aims to tame, subdue, and if necessary, murder human vitalities. Through an exploration of such cultural phenomena as footbinding, reality television, and the construction of robots, Kaplan demonstrates how, in a technology-driven world, an understanding of the fetishism strategy can help to preserve the human dialogue that is the basis of all human relationships. Kaplan writes from the heart as well as from the intellect.

This book covers the principles of advanced 3D fabrication techniques, stem cells and biomaterials for neural engineering. Renowned contributors cover topics such as neural tissue regeneration, peripheral and central nervous system repair, brain-machine interfaces and in vitro nervous system modeling. Within these areas, focus remains on exciting and emerging technologies such as highly developed neuroprostheses and the communication channels between the brain and prostheses, enabling technologies that are beneficial for development of therapeutic interventions, advanced fabrication techniques such as 3D bioprinting, photolithography, microfluidics, and subtractive fabrication, and the engineering of implantable neural grafts.There is a strong focus on stem cells and 3D bioprinting technologies throughout the book, including working with embryonic, fetal, neonatal, and adult stem cells and a variety of sophisticated 3D bioprinting methods for neural engineering applications. There is also a strong focus on biomaterials, including various conductive biomaterials and biomimetic nanomaterials such as carbon-based nanomaterials and engineered 3D nanofibrous scaffolds for neural tissue regeneration. Finally, two chapters on in vitro nervous system models are also included, which cover this topic in the context of studying physiology and pathology of the human nervous system, and for use in drug discovery research. This is an essential book for biomedical engineers, neuroscientists, neurophysiologists, and industry professionals.

Biopolymers from Renewable Resources is a compilation of information on the diverse and useful polymers derived from agricultural, animal, and microbial sources. The volume provides insight into the diversity of polymers obtained directly from, or derived from, renewable resources. The beneficial aspects of utilizing polymers from renewable resources, when considering synthesis, pro cessing, disposal, biodegradability, and overall material life-cycle issues, suggests that this will continue to be an important and growing area of interest. The individual chapters provide information on synthesis, processing and properties for a variety of polyamides, polysaccharides, polyesters and polyphenols. The reader will have a single volume that provides a resource from which to gain initial insights into this diverse field and from which key references and contacts can be drawn. Aspects of biology, biotechnology, polymer synthesis, polymer processing and engineering, mechanical properties and biophysics are addressed to varying degrees for the specific biopolymers. The volume can be used as a reference book or as a teaching text. At the more practical level, the range of important materials derived from renewable resources is both extensive and impressive. Gels, additives, fibers, coatings and films are generated from a variety of the biopolymers reviewed in this volume. These polymers are used in commodity materials in our everyday lives, as well as in specialty products."

"Food and Gender: identity and power" marks the inaugural volume in the "Food in history and culture" book series. The series will anthologize articles originally published in the journal "Food and foodways". This volume examines, among other things, the significance of food centred activities to gender relations and the construction of gendered identities across cultures. "Food and gender: identity and power" examines how each gender's relationship to food may facilitate mutual respect or produce gender hierarchy. This relationship is considered through two central questions. How does control of food production, distribution, and consumption contribute to men's and women's power and social position? and how does food symbolically connote maleness and femaleness and establish the social value of men and women?;Other issues discussed include evaluating men's and women's attitudes about their bodies and the legitimacy of their appetites.

The Advanced Practice Registered Nurse as a Prescriber is an authoritative reference guide designed for students and practicing APRNs alike--delivering the evidence-based information required for informed and ethical prescribing of medication in various clinical settings. It assists the reader to identify and avoid common prescribing mistakes and pitfalls whilst presenting specific strategies to respond appropriately to an array of typical clinical experiences.This revised second edition includes new and expanded chapters with information on authorizing medical marijuana, prescription monitoring programs, electronic prescribing, prescribing globally and issues surrounding controlled substance prescribing and prescribing for opioid use disorder. This leading single-volume resource: Addresses the opportunities, challenges and responsibilities that APRNs face as prescribers Covers the laws, regulations, and professional issues that affect prescribing Discusses global approaches to registered nurse and APRN prescribing such as task sharing, formularies, and independent authority Guides APRNs through difficult clinical situations such as patients seeking controlled substances and requesting inappropriate care Navigates the multiple facets of prescribing controlled substances Examines the role of the APRN in states with medical marijuana laws Serves as a resource to engage in advocacy for fully autonomous prescribing The Advanced Practice Registered Nurse as a Prescriber is essential reading for APRN and pharmacotherapeutics students, registered nurses transitioning to the role of APRN prescriber, and all APRNs including Nurse Practitioners (NP), Clinical Nurse Specialists (CNS), and Certified Registered Nurse Anesthetists (CRNA).

Apprenticeship or vocational training is a subject of lively debate. Economic historians tend to see apprenticeship as a purely economic phenomenon, as an 'incomplete contract' in need of legal and institutional enforcement mechanisms. The contributors to this volume have adopted a broader perspective. They regard learning on the shop floor as a complex social and cultural process, to be situated in an ever-changing historical context. The results are surprising. The authors convincingly show that research on apprenticeship and learning on the shop floor is intimately associated with migration patterns, family economy and household strategies, gender perspectives, urban identities and general educational and pedagogical contexts.

"Food and Gender: identity and power" marks the inaugural volume in the "Food in history and culture" book series. The series will anthologize articles originally published in the journal "Food and foodways". This volume examines, among other things, the significance of food centred activities to gender relations and the construction of gendered identities across cultures. "Food and gender: identity and power" examines how each gender's relationship to food may facilitate mutual respect or produce gender hierarchy. This relationship is considered through two central questions. How does control of food production, distribution, and consumption contribute to men's and women's power and social position? and how does food symbolically connote maleness and femaleness and establish the social value of men and women?;Other issues discussed include evaluating men's and women's attitudes about their bodies and the legitimacy of their appetites.

A revised edition of Kaplan's landmark historiographical text on eighteenth-century French political economy, featuring a significant new introduction by the author.Steven L. Kaplan is the Goldwin Smith Professor of European History at Cornell University and Visiting Professor of Modern History at the University of Versailles, Saint-Quentin.

This book covers the principles of advanced 3D fabrication techniques, stem cells and biomaterials for neural engineering. Renowned contributors cover topics such as neural tissue regeneration, peripheral and central nervous system repair, brain-machine interfaces and in vitro nervous system modeling. Within these areas, focus remains on exciting and emerging technologies such as highly developed neuroprostheses and the communication channels between the brain and prostheses, enabling technologies that are beneficial for development of therapeutic interventions, advanced fabrication techniques such as 3D bioprinting, photolithography, microfluidics, and subtractive fabrication, and the engineering of implantable neural grafts.There is a strong focus on stem cells and 3D bioprinting technologies throughout the book, including working with embryonic, fetal, neonatal, and adult stem cells and a variety of sophisticated 3D bioprinting methods for neural engineering applications. There is also a strong focus on biomaterials, including various conductive biomaterials and biomimetic nanomaterials such as carbon-based nanomaterials and engineered 3D nanofibrous scaffolds for neural tissue regeneration. Finally, two chapters on in vitro nervous system models are also included, which cover this topic in the context of studying physiology and pathology of the human nervous system, and for use in drug discovery research. This is an essential book for biomedical engineers, neuroscientists, neurophysiologists, and industry professionals.

Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.

Biopolymers from Renewable Resources is a compilation of information on the diverse and useful polymers derived from agricultural, animal, and microbial sources. The volume provides insight into the diversity of polymers obtained directly from, or derived from, renewable resources. The beneficial aspects of utilizing polymers from renewable resources, when considering synthesis, pro cessing, disposal, biodegradability, and overall material life-cycle issues, suggests that this will continue to be an important and growing area of interest. The individual chapters provide information on synthesis, processing and properties for a variety of polyamides, polysaccharides, polyesters and polyphenols. The reader will have a single volume that provides a resource from which to gain initial insights into this diverse field and from which key references and contacts can be drawn. Aspects of biology, biotechnology, polymer synthesis, polymer processing and engineering, mechanical properties and biophysics are addressed to varying degrees for the specific biopolymers. The volume can be used as a reference book or as a teaching text. At the more practical level, the range of important materials derived from renewable resources is both extensive and impressive. Gels, additives, fibers, coatings and films are generated from a variety of the biopolymers reviewed in this volume. These polymers are used in commodity materials in our everyday lives, as well as in specialty products."

This volume examines, among other things, the significance of food-centered activities to gender relations and the construction of gendered identities across cultures. It considers how each gender's relationship to food may facilitate mutual respect or produce gender hierarchy. This relationship is considered through two central questions: How does control of food production, distribution, and consumption contribute to men's and women's power and social position? and How does food symbolically connote maleness and femaleness and establish the social value of men and women? Other issues discussed include men's and women's attitudes towards their bodies and the legitimacy of their appetites.

This study takes a fresh look at the origins of modern journalism's ideals and political practices. The book also provides fresh insights into the economics of journalism and documents the changes in political content of the press by a systematic content analysis of newspaper news and editorials over a span of 55 years. The book concludes by exploring the appropriate political role and professional ethics of journalists in a modern democracy.

This study takes a fresh look at the origins of modern journalism's ideals and political practices. The book also provides fresh insights into the economics of journalism and documents the changes in political content of the press by a systematic content analysis of newspaper news and editorials over a span of 55 years. The book concludes by exploring the appropriate political role and professional ethics of journalists in a modern democracy.

When patriarchy makes monsters, sometimes the monsters bite back in the bold debut graphic novel by Jude Ellison S. Doyle with artist A.L. Kaplan! Dragged by her sister Wendy to a feminist retreat on a remote island of Antgitia, Marion Angela Weber is seeking perspective and empowerment, but a disastrous first night leaves her frightfully changed. In the aftermath of an assault, Marion begins to transform as an unspeakable hunger crawls through her body. When the townsfolk recognize there's something different about Marion, they react with suspicion, then violence, while ignoring the monsters already among them. Critically acclaimed journalist/opinion writer Jude Ellison S. Doyle (Dead Blondes and Bad Mothers) with artist A.L. Kaplan (Full Spectrum Therapy, Heart of Gold), and colorist Fabian Mascolo (Firefly: Brand New 'Verse) unleash Maw, a status-quo-shattering tale examining the consequences of sexist violence and the subjugation of marginalized genders, and what happens when the wounded are backed into a corner. Collects the complete Maw #1-5.