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Finalist: 2016 Cybil Awards Part counting game, part guessing game,
this delightful board book invites little ones to look at one
thing, and guess what else it could be. Each page shows one shape,
and then unfolds to reveal an ingenious surprise, sure to captivate
curious toddlers.
What could be more exciting to a toddler than animals that turn
into dinosaurs? Every animal in this book looks cute and
small-until you unfold the flaps to reveal a much bigger dinosaur
within! Is that a jellyfish or a Pterodactyl? Is that a parrot or a
Triceratops? Open the flaps to find out...
In this clever book of die-cut shapes, you can see how a watermelon
changes into a bird's beak-or how a tulip becomes a mermaid's tail.
The pages connect to each other not only with their die-cut holes
but also with zippy, rhyming text that makes for loads of fun.
Filled with colorful art, this is a book that's pleasing to the
eyes, the ears, and the fingers.
Everyone knows the sun is hot. But open the flaps in this book and
you may find a chilly surprise instead! Each spread of this
cleverly designed board book reveals a surprising opposite that
makes for a truly original way for toddlers to learn about words
and concepts. Whether it be hot or cold, clean or dirty, slow or
fast, this book has you covered-at least until you open the flaps.
A review of the current state of the clinical and basic science of
the pharmacology of sleep. The information provided ranges from a
historical perspective to current concepts of sleep mechanisms,
including the interaction between pharmacology and sleep-wake
regulation and between chronopahrmacology and sleep-wake rhythms.
For the first time in one single volume, both the basic mechanisms
of sleep, and the basic and clinical aspects of the pharmacology of
sleep are dealt with in a thorough, comprehensive and authoritative
manner. The chapters, written by the foremost scientific
authorities in this field, integrate the latest information on the
basic mechanisms of drugs as they relate to their effects on sleep.
The last four decades have witnessed considerable advances in our
knowledge of the pharmacology of sleep. Both basic and clinical
pharmacology have made major contributions toward our current
understanding of the complex mechanisms of sleep and wakefulness.
In addition, these advances in our understanding of the
pharmacology of sleep have benefited the treatment of sleep
disorders and various neurologic and psychiatric conditions. This
volume is organized into three different parts. The first is a
review of the basic mechanisms of sleep and wakefulness and the
chronobiology of sleep. The second part reviews the basic
pharmacology of the various neuro transmitter systems involved in
sleep and wakefulness, while the third is clinically oriented and
focuses on the effects of a variety of drugs on sleep and
wakefulness. The initial part begins with a historical review of
the hypotheses of the mechanisms of sleep, evolving from passive to
active regulation, and concepts involving sleep-related
neurotransmitters and other sleep factors. Then regulation of sleep
and wakefulness is discussed in terms of homeostatic, circadian,
and ultradian processes. Also discussed is the fact that sleep
homeostasis is not disrupted by the administration of hypnotic
drugs. This part also reviews time-dependent properties of
pharmacologic agents in relation to endogenous biologic rhythms and
more specifically to chrono pharmacologic changes."
Is that a little boat, or a huge ship? Is that a small house, or a
small house being hoisted by a giant crane? Each spread of this
cleverly designed board book reveals a surprising size opposite
that makes for a novel way for toddlers to learn about words and
concepts. Here's a lift-the-flap board book that's bigger-and
smaller-than the average concept book.
Fans of Agnese Baruzzi's imaginative board books will "gobble up"
this lively book about a wolf whose eyes and appetite are bigger
than his stomach. In this hilarious lift-the-flap board book, a
HUNGRY wolf is ready to devour whatever animal crosses his path,
with a quick "chomp, chomp!" But when he gobbles up one creature
who's a little more challenging than he imagines, the wolf may have
to rethink his diet altogether. Children will love lifting the
flaps of this book to find out who's on the menu, and what happens
when one hungry wolf meets his match.
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