The last four decades have witnessed considerable advances in our knowledge of the pharmacology of sleep. Both basic and clinical pharmacology have made major contributions toward our current understanding of the complex mechanisms of sleep and wakefulness. In addition, these advances in our understanding of the pharmacology of sleep have benefited the treatment of sleep disorders and various neurologic and psychiatric conditions. This volume is organized into three different parts. The first is a review of the basic mechanisms of sleep and wakefulness and the chronobiology of sleep. The second part reviews the basic pharmacology of the various neuro transmitter systems involved in sleep and wakefulness, while the third is clinically oriented and focuses on the effects of a variety of drugs on sleep and wakefulness. The initial part begins with a historical review of the hypotheses of the mechanisms of sleep, evolving from passive to active regulation, and concepts involving sleep-related neurotransmitters and other sleep factors. Then regulation of sleep and wakefulness is discussed in terms of homeostatic, circadian, and ultradian processes. Also discussed is the fact that sleep homeostasis is not disrupted by the administration of hypnotic drugs. This part also reviews time-dependent properties of pharmacologic agents in relation to endogenous biologic rhythms and more specifically to chrono pharmacologic changes."

What could be more exciting to a toddler than animals that turn into dinosaurs? Every animal in this book looks cute and small-until you unfold the flaps to reveal a much bigger dinosaur within! Is that a jellyfish or a Pterodactyl? Is that a parrot or a Triceratops? Open the flaps to find out...

Finalist: 2016 Cybil Awards Part counting game, part guessing game, this delightful board book invites little ones to look at one thing, and guess what else it could be. Each page shows one shape, and then unfolds to reveal an ingenious surprise, sure to captivate curious toddlers.

A review of the current state of the clinical and basic science of the pharmacology of sleep. The information provided ranges from a historical perspective to current concepts of sleep mechanisms, including the interaction between pharmacology and sleep-wake regulation and between chronopahrmacology and sleep-wake rhythms. For the first time in one single volume, both the basic mechanisms of sleep, and the basic and clinical aspects of the pharmacology of sleep are dealt with in a thorough, comprehensive and authoritative manner. The chapters, written by the foremost scientific authorities in this field, integrate the latest information on the basic mechanisms of drugs as they relate to their effects on sleep.

Everyone knows the sun is hot. But open the flaps in this book and you may find a chilly surprise instead! Each spread of this cleverly designed board book reveals a surprising opposite that makes for a truly original way for toddlers to learn about words and concepts. Whether it be hot or cold, clean or dirty, slow or fast, this book has you covered-at least until you open the flaps.

Is that a little boat, or a huge ship? Is that a small house, or a small house being hoisted by a giant crane? Each spread of this cleverly designed board book reveals a surprising size opposite that makes for a novel way for toddlers to learn about words and concepts. Here's a lift-the-flap board book that's bigger-and smaller-than the average concept book.

Fans of Agnese Baruzzi's imaginative board books will "gobble up" this lively book about a wolf whose eyes and appetite are bigger than his stomach. In this hilarious lift-the-flap board book, a HUNGRY wolf is ready to devour whatever animal crosses his path, with a quick "chomp, chomp!" But when he gobbles up one creature who's a little more challenging than he imagines, the wolf may have to rethink his diet altogether. Children will love lifting the flaps of this book to find out who's on the menu, and what happens when one hungry wolf meets his match.