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Cationic antimicrobial peptides are multifunctional peptides of the
innate immune system, which not only act directly against
microorganisms, but also signal between early and late immune
responses and modulate inflammatory reposnes. The significance of
these host defence peptides in combating infection and in
host-microbe homeostasis has become increasingly clear, through
advances made by microbiologists, biochemists, biophysicists,
immunologists, molecular biologists, and a range of medical and
pharmaceutical researchers. This book, drawing together
contributions from leading scientists, reviews significant recent
advances in our knowledge of mammalian antimicrobial peptides. In
addition to providing up-to-date overviews of their structure,
expression and biology, their multiple activities and interactions
with microbial populations as well as their potential application
as novel therapeutic agents are summarized. Chapters describing
developments using animal models and investigations of the roles of
these host defence peptides in microbial infections are
complemented by chapters addressing their mechanisms of action and
of microbial resistance.
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