Up to 40 volumes are planned for this concise monograph series, which focuses on the implementation of various engineering principles in the conception, design, development, analysis and operation of biomedical, biotechnological and nanotechnology systems and applications. In this monograph, the authors discuss the current progress in the medical application of impedimetric biosensors, along with the key challenges in the field. First, a general overview of biosensor development, structure and function is presented, followed by a detailed discussion of impedimetric biosensors and the principles of electrochemical impedance spectroscopy. Next, the current state-of-the art in terms of the science and technology underpinning impedance-based biosensors is reviewed in detail. The layer-by-layer construction of impedimetric sensors is described, including the design of electrodes, their nano-modification, transducer surface functionalisation and the attachment of different bioreceptors. The current challenges of translating lab-based biosensor platforms into commercially-available devices that function with real patient samples at the POC are presented; this includes a consideration of systems integration, microfluidics and biosensor regeneration. The final section of this monograph describes case studies of successful impedance-based biosensors for the detection of a range of analytes from small molecules up to whole microorganisms. Finally, the authors put forward future perspectives for the clinical applications of impedimetric biosensors.

In the last decade, remarkable advances have been made in bone marrow transplantation (BMT), which is now becoming a powerful tool in the treatment of diseases such as leukemia, aplastic anemia, and congenital immunodeficiency. In animal experiments, it has been found that BMT can be used to treat not only systemic autoimmune diseases but also organ-specific autoimmune diseases. In humans, it has recently been shown that rheumatoid arthritis, ulcerative colitis, and Crohn's disease can be successfully treated after BMT. This volume contains new information on how to prevent graft rejection, how T cell functions can be completely restored, and how concomitant BMT can prevent the rejection of organ allografts without the use of immunosuppressive agents. BMT will become an increasingly useful and powerful treatment for various currently intractable diseases, and this book will contribute by providing details of the latest research in the field.

Cytokine involvement in the immune system's response to stress is now very well documented. Cytokine activity has been implicated in a variety of mental and physical diseases, and has been shown to have a significant role in fueling the vicious circle of depression and illness. The first edition of Cytokines: Stress and Immunity pointed out that the immune system does not stand alone, but is profoundly affected by other organ systems, especially the central nervous and the neuroendocrine systems, with cytokines being the common tool of communication. This edition continues on the trailblazing path of the original to once again present current research that informs our evolving understanding of how cytokines function and the clinical implications of cytokine activity. Completely rewritten by the top authorities in their fields, this volume includes 16 entirely new chapters, which document dramatic new developments. It provides a comprehensive overview of the role of cytokines in the neuroendocrine and immune systems, while also addressing the interactions between these systems. It examines cytokine activity and clinical implications from a number of perspectives, including those of immunology, pharmacology, oncology, endocrinology, and psychiatry. Researchers involved with the most specific aspects of cell signaling as well clinicians dealing with the effects of immunosuppression-related diseases will find a wealth of interesting and instantly applicable information. This new edition begins with an extended dedication and tribute to the late Robert A. Good, the father of modern immunology. It documents the life and groundbreaking achievements of Dr. Good who served as an editor for boththe former and current editions of this work.

A Search for Unity in Diversity examines the traditional readings of John Dewey's relationship to Hegel and demonstrates that Dewey's later pragmatism was a development of the historicist/humanistic Hegel, rather than a turning away from Hegelian philosophy. Good argues that Dewey drew upon resources he found in the writings of St. Louis Hegelians to fashion a non-metaphysical reading of Hegel. A Search for Unity in Diversity reasons that Hegel encouraged Dewey to understand philosophy as an exercise in individual and cultural reconstruction. Beyond exposing fatal flaws in the traditional reading of Dewey's relationship to Hegel, Good shows that Dewey's pragmatism is a development, rather than a rejection, of Hegel's philosophy. This not only explains Dewey's Hegelian deposit, it also sheds light on why recent Hegel scholars have found elements of pragmatism in Hegel's thought and provides grounds for rapprochment between American pragmatism and Continental European philosophy.

A Search for Unity in Diversity examines the traditional readings of John Dewey's relationship to Hegel and demonstrates that Dewey's later pragmatism was a development of the historicist/humanistic Hegel, rather than a turning away from Hegelian philosophy. Good argues that Dewey drew upon resources he found in the writings of St. Louis Hegelians to fashion a non-metaphysical reading of Hegel. A Search for Unity in Diversity reasons that Hegel encouraged Dewey to understand philosophy as an exercise in individual and cultural reconstruction. Beyond exposing fatal flaws in the traditional reading of Dewey's relationship to Hegel, Good shows that Dewey's pragmatism is a development, rather than a rejection, of Hegel's philosophy. This not only explains Dewey's Hegelian deposit, it also sheds light on why recent Hegel scholars have found elements of pragmatism in Hegel's thought and provides grounds for rapprochment between American pragmatism and Continental European philosophy.

In two millenia, our knowledge of the planet and its natural laws and forces has undergone remarkable changes. This unique reference work charts this remarkable intellectual progression. By exploring the physical phenomena that inform our knowledge and summarising historical explanations this Encyclopedia presents the history of the study of the earth from antiquity to the space age. The wide-ranging articles summarise subjects as diverse as geography, imperialism, environmentalism, computers, meterology, ozone formation theories since 1800, scientific rocketry and the Scopes trial.

Cytokine involvement in the immune system's response to stress is now very well documented. Cytokine activity has been implicated in a variety of mental and physical diseases, and has been shown to have a significant role in fueling the vicious circle of depression and illness. The first edition of Cytokines: Stress and Immunity pointed out that the immune system does not stand alone, but is profoundly affected by other organ systems, especially the central nervous and the neuroendocrine systems, with cytokines being the common tool of communication. This edition continues on the trailblazing path of the original to once again present current research that informs our evolving understanding of how cytokines function and the clinical implications of cytokine activity. Completely rewritten by the top authorities in their fields, this volume includes 16 entirely new chapters, which document dramatic new developments. It provides a comprehensive overview of the role of cytokines in the neuroendocrine and immune systems, while also addressing the interactions between these systems. It examines cytokine activity and clinical implications from a number of perspectives, including those of immunology, pharmacology, oncology, endocrinology, and psychiatry. Researchers involved with the most specific aspects of cell signaling as well clinicians dealing with the effects of immunosuppression-related diseases will find a wealth of interesting and instantly applicable information. This new edition begins with an extended dedication and tribute to the late Robert A. Good, the father of modern immunology. It documents the life and groundbreaking achievements of Dr. Good who served as an editor for both the former and current editions of this work.

By 1940, immunological mechanisms had been proved to have fundamental influ ences on a great number and variety of skin reactions, and skin diseases had brought to light a great number of fundamental immunological mechanisms that were basic to a wide range of different diseases, dermatological and nondermato logical. The preeminence of dermatological research in the advancement of immu nological knowledge should not astonish anyone. For the skin is not only the most easily accessible tissue for producing and studying immunological reactions, it is also the great organ of protection that meets the first onslaughts of inimical environmental forces and agents-potential enemies, both living and dead. And protection is in essence what immunology is all about. To get an idea of the long-established role that testing the skin and the study of its many reactions has played in advancing general immunology, one need recall only smallpox vaccination; tuberculin testing; testing with fungal extracts; skin testing in hay fever, asthma, and serum sickness; skin tests with toxins and toxoids; the patch test; the passive transfer of skin-adhering antibodies (reagins); skin sensitization by simple chemicals; and similar dermatological procedures that have exerted their influence on medical and scientific disciplines far beyond dermatology.

In the last decade, remarkable advances have been made in bone marrow transplantation (BMT), which is now becoming a powerful tool in the treatment of diseases such as leukemia, aplastic anemia, and congenital immunodeficiency. In animal experiments, it has been found that BMT can be used to treat not only systemic autoimmune diseases but also organ-specific autoimmune diseases. In humans, it has recently been shown that rheumatoid arthritis, ulcerative colitis, and Crohn's disease can be successfully treated after BMT. This volume contains new information on how to prevent graft rejection, how T cell functions can be completely restored, and how concomitant BMT can prevent the rejection of organ allografts without the use of immunosuppressive agents. BMT will become an increasingly useful and powerful treatment for various currently intractable diseases, and this book will contribute by providing details of the latest research in the field.

The question of how far Dewey's thought is indebted to Hegel has long been a conundrum for philosophers. This book shows that, far from repudiating Hegel, Dewey's entire pragmatic philosophy is premised on a "philosophy of spirit" inspired by Hegel's project. Two essays by Shook and Good defending this radical viewpoint are joined by the definitive text of Dewey's 1897 Lecture at the University of Chicago on Hegel's "Philosophy of Spirit." Previously cited by scholars only from the archival manuscript, this edited Lecture is now available to fully expose the basic concern shared by Hegel and Dewey for the full and free development of the individual in the social context. Dewey's and Hegel's philosophies are at the center of modern philosophy's hopes for advancing human freedom.

Observing variable stars is one of the major contributions amateur astronomers make to science. There are 36,000 variable stars listed in the General Catalogue of Variable Stars, so it is clearly impossible for the limited number of professional observatories to target even the majority of them. That's where amateur astronomers come in - thousands of them turning their telescopes to the sky every night. Variable star observing is the most popular of "real science" activities for amateurs, and Gerry Good's book provides everything needed. The first part of the book provides a highly detailed account of the various classes of variable star, with examples, illustrations and physical descriptions. The second section covers practical aspects of observing, everything from preparation and planning, through observing techniques, to data management and reduction.

"When Harry Met Sally" is only the most iconic of popular American movies, books, and articles that pose the question of whether friendships between men and women are possible. In Founding Friendships, Cassandra A. Good shows that this question was embedded in and debated as far back as the birth of the American nation. Indeed, many of the nation's founding fathers had female friends but popular rhetoric held that these relationships were fraught with social danger, if not impossible. Elite men and women formed loving, politically significant friendships in the early national period that were crucial to the individuals' lives as well as the formation of a new national political system, as Cassandra Good illuminates. Abigail Adams called her friend Thomas Jefferson "one of the choice ones on earth," while George Washington signed a letter to his friend Elizabeth Powel with the words "I am always Yours." Their emotionally rich language is often mistaken for romance, but by analyzing period letters, diaries, novels, and etiquette books, Good reveals that friendships between men and women were quite common. At a time when personal relationships were deeply political, these bonds offered both parties affection and practical assistance as well as exemplified republican values of choice, freedom, equality, and virtue. In so doing, these friendships embodied the core values of the new nation and represented a transitional moment in gender and culture. Northern and Southern, famous and lesser known, the men and women examined in Founding Friendships offer a fresh look at how the founding generation defined and experienced friendship, love, gender, and power.

American popular culture is filled with movies, books, and articles asking whether friendships between men and women are possible. In Founding Friendships, Cassandra Good demonstrates that this is hardly a new issue; indeed, many of the nation's founding fathers had female friends. Elite men and women over two hundred years ago formed loving, politically significant friendships. Abigail Adams called her friend Thomas Jefferson "one of the choice ones on earth," while George Washington signed a letter to his friend Elizabeth Powel with the words "I am always Yours." The emotionally rich language of this period is often mistaken for romance, but this book's innovative analysis of letters, diaries, poetry, and novels in the past reveals that friendships between men and women were quite common. At a time when personal relationships were deeply political, these friendships embodied the core values of the new nation. Founding Friendships offers a fresh and expansive look at how America's founding generation of men and women defined and experienced friendship, love, gender, and power in the new nation.

The question of how far Dewey's thought is indebted to Hegel has long been a conundrum for philosophers. This book shows that, far from repudiating Hegel, Dewey's entire pragmatic philosophy is premised on a "philosophy of spirit" inspired by Hegel's project. Two essays by Shook and Good defending this radical viewpoint are joined by the definitive text of Dewey's 1897 Lecture at the University of Chicago on Hegel's "Philosophy of Spirit." Previously cited by scholars only from the archival manuscript, this edited Lecture is now available to fully expose the basic concern shared by Hegel and Dewey for the full and free development of the individual in the social context. Dewey's and Hegel's philosophies are at the center of modern philosophy's hopes for advancing human freedom.

L'osservazione delle stelle variabili e uno dei principali contributi che gli astronomi dilettanti possono offrire alla scienza e questo libro fornisce tutte le informazioni necessarie per dedicarvisi con profitto.

Nella prima parte vengono presentate in dettaglio le diverse classi di variabili, con esempi, curve di luce e descrizioni fisiche. La seconda sezione copre invece tutti gli aspetti pratici dell'osservazione: dalla preparazione e la pianificazione, alle tecniche osservative, fino alla gestione e all'elaborazione dei dati.

Questo e un volume indispensabile e completo per chi voglia impegnarsi nell'osservazione delle stelle variabili, adatto per tutti gli astrofili, dai principianti fino a quelli che hanno gia maturato un discreto livello d'esperienza e di abilita.

This report is intended to inform present and future National Park Service personnel concerning the history, challenges, and circumstances surrounding the development of the New River Gorge National River (NERI) and its sister units Gauley River National Recreation Area (GARI) and Bluestone National Scenic River (BLUE). It provides background understanding of the natural and human histories of the area, of how these have related to administration of the park, and how park administration has developed in interaction with contemporary issues and concerns.

Beginning in 1900, three generations of an ordinary family living in occupied Poland inadvertently become embroiled in a world of geopolitical intrigue, leading to a daring escape, emigration to Canada and the USA, involvement in the arms development business and military espionage.
Taken from his parents as a young boy in occupied Poland, Erik Berglund is schooled by the Prussian state for ten years and develops a talent for arms design. Soon he finds himself pulled by circumstances and faced with difficult choices arising from his conflicting allegiances to his Prussian benefactors and his family homeland. Persuaded by an influential family member and Polish patriot, Erik comes up with a perfect plan for escape. In Toledo he starts a family and continues his innovations in weapons design. But even this land of new opportunities cannot help him evade the powers of the dark tides.
Years later, Erik's son Walter has grown up into a young man on his uncle's homestead in Manitoba, Canada. As Walter tries to piece together the mystery of his parents' deaths, he is drawn away from his pastoral life as a farm boy and transformed into a top-notch spy. As an undercover operative in pre-WWII Germany and Poland, he finds himself deep in the dangerous waters of Nazi Germany's illegal rearmament and its ugly anti-Semetic agenda. Driven by a passion for revenge, Walter lands in some very tight situations which he escapes only with the support of a trustworthy ally. But in the end, like his father, Walter is alone to deal with his entangled political and personal identity, and the age-old hostilities, prejudices and intolerances that he and the rest of the world have inherited.

Public money is one of the primary currencies of influence for politicians and public servants. It affects the standards by which they undertake the nation's business and impacts the standard of living of the nation's citizens. David A. Good's The Politics of Public Money examines the extent to which the Canadian federal budgetary process is shifting from one based on a bilateral relationship between departmental spenders and central guardians to one based on a more complex, multilateral relationship involving a variety of players. This new edition offers an up-to-date account of the Canadian system, including the creation of the Parliamentary Budget Officer, the government's response to the global financial crisis, Canada's Economic Action Plan, strategic and operating reviews, the most recent attempts to reform the Estimates, and much more. An insightful and incisive study of the changing budgetary process, The Politics of Public Money examines the promises and pitfalls of budgetary reform and sheds new light on the role insiders play in influencing government spending.

The Museum of Vertebrate Zoology (MVZ), located on the campus of the University of California, Berkeley, is a leading center of herpetological research in the United States. This monograph offers a brief account of the principal figures associated with the collection and of the most important events in the history of herpetology in the MVZ during its first 93 years, and lists all type specimens of recent amphibians and nonavian reptiles in the collection.
Although the MVZ has existed since 1908, until 1945 there was no formal curator for the collection of amphibians and nonavian reptiles. Since that time Robert C. Stebbins, David B. Wake, Harry W. Greene, JavierA A. Rodriguez-Robles (inA an interim capacity), and Craig Moritz have served in that position.
The herpetological collection of the MVZ was begun on March 13, 1909, with a collection of approximately 430 specimens from southern California and as of December 31, 2001, contained 232,254 specimens. Taxonomically, the collection is strongest in salamanders, accounting for 99,176 specimens, followed by "lizards" (squamate reptiles other than snakes and amphisbaenians, 63,439), frogs (40,563), snakes (24,937), turtles (2,643), caecilians (979), amphisbaenians (451), crocodilians (63), and tuataras (3). Whereas the collection's emphasis historically has been on the western United States and on California in particular, representatives of taxa from many other parts of the world are present.
The 1,765 type specimens in the MVZ comprise 120 holotypes, three neotypes, three syntypes, and 1,639 paratopotypes and paratypes; 83 of the holotypes were originally described as full species. Of the 196 amphibian and nonavian reptiliantaxa represented by type material, most were collected in Mexico (63) and California (USA, 54).
The Appendix of the monograph presents a list of curators, graduate and undergraduate students, postdoctoral fellows, research associates, research assistants, curatorial associates, curatorial assistants, and visiting faculty who have conducted research on the biology of amphibians and reptiles while in residence in the Museum of Vertebrate Zoology as of December 31, 2001.

This unique volume contains reviews by some of the most prominent immunologists in the world. The authors present vital facts for each of their areas of expertise and provide individual perspectives on how their own contributions were developed and how these contributions influenced general immunological thinking and development. This impressive collection of personal reviews by these internationally renowned immunologists makes The Immunologic Revolution an important and lasting contribution to the entire biomedical community.