Medicinal Chemistry: A Look at How Drugs Are Discovered is written for those who are interested in learning how drugs are discovered. Compared to other books on the market, this text takes a different approach by presenting the subject on chemical reaction mechanism terms, which ideally makes the subject matter more interesting and easier to comprehend. The authors describe the drug discovery process, from advancing an initial lead to the approval process, and include drug discovery sources. Additional features: Explains medicinal chemistry on chemical mechanism terms, allowing for a more interesting and easier to comprehend text Includes valuable insights toward the various pathways taken at pharmaceutical industries in drug discoveries Improved by including questions raised and suggestions made from students in the authors' medicinal chemistry classes This book will benefit both upper level undergraduates and graduates studying in the fields of medicinal chemistry and drug discovery, as well as scientists working in the pharmaceutical industry.

Medicinal Chemistry: A Look at How Drugs Are Discovered is written for those who are interested in learning how drugs are discovered. Compared to other books on the market, this text takes a different approach by presenting the subject on chemical reaction mechanism terms, which ideally makes the subject matter more interesting and easier to comprehend. The authors describe the drug discovery process, from advancing an initial lead to the approval process, and include drug discovery sources. Additional features: Explains medicinal chemistry on chemical mechanism terms, allowing for a more interesting and easier to comprehend text Includes valuable insights toward the various pathways taken at pharmaceutical industries in drug discoveries Improved by including questions raised and suggestions made from students in the authors' medicinal chemistry classes This book will benefit both upper level undergraduates and graduates studying in the fields of medicinal chemistry and drug discovery, as well as scientists working in the pharmaceutical industry.

Discussing strategies to determine the structure and machanisms of numerous compound classics, this book covers new chemical and elctrophoretic techniques for rapid sample preconcentration and separation. It summarizes breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications, provides practical examples for the characterization of peptides, proteins, and glycoproteins, includes applications in proteomics, combinatorial chemistry, and drug characterization. Topics include chemical and electrophoretic techniques for rapid sample preconcentration and separation, screening processes for proteins from libraries of compounds, protein folding and dynamics, and more.

The book 'Kashmir Face-Off India's Quandary' is about Kashmir. How it remained in the suspended, animated state since 1947 in three parts Pakistan Occupied Kashmir, China Occupied Kashmir and rightfully held Indian Jammu and Kashmir. So many years have passed in status quo state and none of the actors is ready to budge an inch. The legal status of Jammu and Kashmir (J&K) as per the documentary evidence and seconded by the British Empire, the day the Maharaja of the State signed the Accord of Accession in 1947 October. This had made both Pakistan and China not recognising the accord. Pakistan invaded India to take by force J&K, Indian Army drove out the invading forces, but as ceasefire came into being certain territories were still held by Pakistan. Same was the case with China who in 1962 captured Aksai Chen and never returned it to India. These occupied territories were and have been used in fermenting problems and instability, based on communal lines with a view to breakaway Kashmir from India. With the abrogation of special status which Pakistan and China have been exploiting, both these countries got the jolt which they were never expecting. It was for the first time India declared the occupied territories as part of India in August 2019 and put the reclamation of the same. In this book, the modus, modalities and way out have been discussed to get back all the occupied territories, even at the cost of going in for forced reclamation. The narrative has been made interesting with Maps and debating the pros and cons, where India stands and what it must do to improving its posturing of reclamations.

The book 'Kashmir Face-Off India's Quandary' is about Kashmir. How it remained in the suspended, animated state since 1947 in three parts Pakistan Occupied Kashmir, China Occupied Kashmir and rightfully held Indian Jammu and Kashmir. So many years have passed in status quo state and none of the actors is ready to budge an inch. The legal status of Jammu and Kashmir (J&K) as per the documentary evidence and seconded by the British Empire, the day the Maharaja of the State signed the Accord of Accession in 1947 October. This had made both Pakistan and China not recognising the accord. Pakistan invaded India to take by force J&K, Indian Army drove out the invading forces, but as ceasefire came into being certain territories were still held by Pakistan. Same was the case with China who in 1962 captured Aksai Chen and never returned it to India. These occupied territories were and have been used in fermenting problems and instability, based on communal lines with a view to breakaway Kashmir from India. With the abrogation of special status which Pakistan and China have been exploiting, both these countries got the jolt which they were never expecting. It was for the first time India declared the occupied territories as part of India in August 2019 and put the reclamation of the same. In this book, the modus, modalities and way out have been discussed to get back all the occupied territories, even at the cost of going in for forced reclamation. The narrative has been made interesting with Maps and debating the pros and cons, where India stands and what it must do to improving its posturing of reclamations.

For thousands of years nature has played an important role in providing mankind with life-saving drugs. Several natural products have been clinically approved and they continue to remain as valuable medicines. However, in cases where the supply of an active natural product is limited, total synthesis is often the only means by which sufficient quantities could be generated for therapeutic use. Additionally, such a process could unveil novel pharmacophores which could serve as templates for designing new drugs. Himbacine, himgaline, and GB13 belong to a family of alkaloids isolated from the bark of a rain forest tree, Galbulimima belgraveana. While himbacine has been extensively studied for its antimuscarinic activity, the biological properties of its more complex congeners remain unexplored. This book describes total syntheses of both the enantiomers of himgaline and GB13. Key manipulations involved a Diels-Alder reaction, an aldol-type cascade cyclization, an aza-Michael reaction, and a hydroxyl-directed stereoselective ketone reduction. This synthetic achievement paves the way for future exploration of the medicinal value of compounds described herein and other related natural products.

Kashmir has always been in the midst of geopolitical hullabaloo due to its pending UN Resolution and now the demand of 'Azadi' (Freedom) which became more pronounced after the inception of insurgency in the State in 1987-88. If we look into the issue, in reality, it is a bilateral issue between India and Pakistan, if the legality reason is applied then there is no doubt that India's stance is most legitimate. The people of Kashmir have invited the 'Jihad' into Indian Kashmir Region and declared 'Azadi' as a war of freedom through the Pakistan sponsored militancy and radicalisation of the society on communal lines by the militant organisations and separatists. In the present environment, the stakeholders are at a tangent and it is mainly because the main stakeholder, the people of Kashmir are uncertain and confused, the total population is not part of the 'Azadi' (freedom) thus there is vagueness and the vision of 'Azadi' (freedom) is very blurred. The other stakeholders are either taking advantage of the people's sentiments or going by their own agenda of self-interest or lack the will to take initiatives to resolve the Kashmir issue which meets their personal ends. In this book, the chapters are based on the stakeholders and their participation in the Kashmir embroil. The basic contents are based on the issues that have made Kashmir an affair of continued existence by various stakeholders, the creation of an environment of stalemate and prevailing status quo without any changes, none of the stakeholders are ready to budge or lose their turf. Written in a simple and lucid manner, the narratives made interesting with historical facts, quotations and factual as prevailing in Kashmir.