Even the most experienced educators struggle with the challenge of designing and delivering meaningful inclusive practices in their school communities and classrooms. How can you deliver meaningful learning experiences that meet the needs of ALL students? The Inclusion Toolbox is an all-in-one resource that combines research-based strategies and practical tools to help teachers design and implement a truly inclusive education program. The Inclusion Toolbox features materials relevant to all grades, disabilities, and stages of implementation, and is organized in a way that allows teachers to start at multiple entry points. Readers will discover: Step-by-step plans for implementing new programs through teambuilding and leadership Guidance on how to maintain, strengthen, and expand existing inclusive programs Strategies to empower and involve families, students with disabilities, and their peers Techniques to create effective and complementary schedules Tools to assess student interests, develop adaptation plans, encourage students to participate in extracurricular activities, and more With user-friendly online resources and practical strategies, this comprehensive guide will help you expand your toolbox, inspire your students, and make inclusion a reality!

About 31% of the patients with a factor VIII replacement therapy develop a factor VIII inhibitor.From these are 23% low-responder (< 5BE) and 77% high-responder (> 5BE) [8].In the case of severe hemophilia B,about 10.5% of the patients develop inhibitory antibodies [9]. Anti-factor VIII-antibodies are also seen in 15-78% healthy people without hemophilia [7, 17, 19]. Lacroix-Desmazes et al. [10, 11] showed anti-idiotypic antibodies neutralizing the inhibitory activity of the an- factor VIII antibodies in healthy people. Well-known predisposing factors for inhibitor formation are genetic features of factor VIII,which include large deletions,nonsense mutations or intrachromosomal recombinations [5, 23].Also, ethnic groups other than Caucasians (e.g.Africans) have a higher risk of developing inhibitors.Other risk factors are presumably de- ved from the immune system. For instance, a reduction of the inhibitor was seen with lower CD4+ T helper cell counts in HIV positive hemophilic patients [3,4].The development of inhibitors is very likely to be a Th-2 mediated event where cyto- nes and their receptors,T-cell receptors and the Major Histocompatibility Complex may also play an important role. Theoretical Background The substituted factor is an unknown protein for patients with a severe he- philia. Fig. 1. The normal immunoresponse (according to BAENKLER [2]) Abbreviations: TCR - T cell-receptor; APC - antigen presenting cell 36 I.Wieland et al.