Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for neuroprotection. While stroke and many other brain injuries are not predictable, in some populations (e.g., metabolic syndrome, patients undergoing carotid endarterectomy, aneurysm clipping, or with recent TIAs) the risk for stroke is identifiable and significant, and preconditioning may represent a useful strategy for neuroprotection. For unpredictable injuries, post-conditioning the brain - or inducing endogenous protective mechanisms after the initial injury - can also abrogate the extent of injury. Finally, remote pre- and post-conditioning methods have been developed in animals, and are now being tested in clinical trials, wherein a brief, noninjurious stress to a noncerebral tissue (i.e., skeletal muscle) can provide protection to the CNS and thereby allows clinicians the opportunity to circumvent concerns regarding the direct preconditioning of neurological tissues.

This book will be useful to anyone who wants to understand the use of quantum theory for the description of physical processes. It is a graduate level text, ideal for independent study, and includes numerous figures, exercises, bibliographical references, and even some computer programs. The first chapters introduce formal tools: the mathematics are precise, but not excessively abstract. The physical interpretation too is rigorous. It makes no use of the uncertainty principle of other ill-defined notions. The central part of the book is devoted to Bell's theorem and to the Kochen-Specker theorem. It is here that quantum phenomena depart most radically from classical physics. There has recently been considerable progress on these issues, and the latest developments have been included. The final chapters discuss further topics of current research: spacetime symmetries, quantum thermodynamics and information theory, semiclassical methods, irreversibility, quantum chaos, and especially the measuring process. In particular, it is shown how modern techniques allow the extraction of more information from a physical system than traditional measurement methods. For physicists, mathematicians and philosophers of science with an interest in the applications and foundations of quantum theory. The volume is suitable as a supplementary graduate textbook.

This book asks why crime and violence persist in Latin America at extreme levels and why the states have not been able to more effectively solve this problem that dominates the lives of many millions of Latin Americans. Informed by diverse disciplinary backgrounds, the book brings together a team of regional experts to discuss research-based explanations on some of Latin America's most pressing criminal and violent issues distressing the rule of law. First, it examines old and new forms of observing crime upon perpetrators and victimized communities. Second, it explores the geographies of urban and rural violence and the entangled politics following organized criminality. Third, it questions how the transfer of policy knowledge and expertise reshapes local security governance, and, more importantly, critically examines the problems in implementing foreign models and paradigms in the Latin American context. Finally, it exposes the everchanging scenario of policy-making and prosecuting crime and homicide. Crime, Violence, and Justice in Latin America provides new themes and novel trends on what crime and violence mean in the eyes of observers, perpetrators, policymakers, governmental officials, and victims. It is an important acquisition for policy makers and academics alike.

This book provides a general overview of several concepts of synchronization and brings together related approaches to secure communication in chaotic systems. This is achieved using a combination of analytic, algebraic, geometrical and asymptotical methods to tackle the dynamical feedback stabilization problem. In particular, differential-geometric and algebraic differential concepts reveal important structural properties of chaotic systems and serve as guide for the construction of design procedures for a wide variety of chaotic systems. The basic differential algebraic and geometric concepts are presented in the first few chapters in a novel way as design tools, together with selected experimental studies demonstrating their importance. The subsequent chapters treat recent applications. Written for graduate students in applied physical sciences, systems engineers, and applied mathematicians interested in synchronization of chaotic systems and in secure communications, this self-contained text requires only basic knowledge of integer ordinary and fractional ordinary differential equations. Design applications are illustrated with the help of several physical models of practical interest.

This edited book addresses the issues of gun trafficking and gun violence across different regions of the world, including the Americas, Africa, Asia, Europe and Oceania. It seeks to identify global key trends on gun trafficking and related violence and discuss different enforcement measures. Each chapter is written by teams of distinguished academics and/or experienced practitioners to include practitioner insights and policy proposals on issues related to gun violence and gun trafficking. Chapters offer an overview of violence and recent gun control debates in the regions, enumerate challenges, provide lessons learnt, and recommend policy solutions. An overview of the global small arms trade is provided at the beginning alongside a comparative analysis of common challenges and significant differences across the regions. This book speaks to those in Criminology, International Relations, Public Policy, International Security, Public health and Law, and to civil society organizations, think tanks, research centers, policy analysts and policy makers involved in gun control debates.

This anthology addresses the role of postsecondary institutional structures and policy in shaping the tenure-track process for Chicana and Latina faculty in higher education. Each chapter offers first-person narratives of survival in the academy employing critical theoretical contributions and qualitative empirical research. Major topics included are the importance of early socialization, intergenerational mentorship, culturally relevant faculty programming, and institutional challenges and support structures. The aim of this volume is to highlight practical and policy implications and interventions for scholars, academics, and institutions to facilitate tenure and promotion for women faculty of color.

Defining organs at risk is a crucial task for radiation oncologists when aiming to optimize the benefit of radiation therapy, with delivery of the maximum dose to the tumor volume while sparing healthy tissues. This book will prove an invaluable guide to the delineation of organs at risk of toxicity in patients undergoing radiotherapy. The first and second sections address the anatomy of organs at risk, discuss the pathophysiology of radiation-induced damage, and present dose constraints and methods for target volume delineation. The third section is devoted to the radiological anatomy of organs at risk as seen on typical radiotherapy planning CT scans, with a view to assisting the radiation oncologist to recognize and delineate these organs for each anatomical region - head and neck, mediastinum, abdomen, and pelvis. The book is intended both for young radiation oncologists still in training and for their senior colleagues wishing to reduce intra-institutional variations in practice and thereby to standardize the definition of clinical target volumes.

There is a great deal more to Cubas place on the global stage than its contentious relationship with the United States. Taking a refreshing look at Cuban international relations, contributors to this volume from both inside and outside the island explore the myriad ways in which it has not only maintained but often increased its reach and influence. In Latin America, Europe, Africa, and Asia, Cuba has assumed a geopolitical role of unlikely prominence. Even in the face of the ongoing U. S. embargo, Cubans have seen improvement in the quality of their lives. Shedding new light on Cuban diplomacy with communist China as well as with Western governments such as Great Britain and Canada, these essays reveal how the promotion of increased economic and political cooperation between Cuba and Venezuela served as a catalyst for the Petrocaribe group. Links established with countries in the Caribbean and Central America have increased tourism, medical diplomacy, and food sovereignty across the region. Cuban transnationalism has also succeeded in creating people-to-people contacts involving those who have remained on the island and members of the Cuban diaspora. While the specifics of Cubas international relations are likely to change as new leaders take over, the role of Cubans working to assert their sovereignty has undoubtedly, as this volume demonstrates, impacted every corner of the globe. Cubas domestic and political successes may even serve as models for other developing countries.

This book constitutes the proceedings of the 39th IFIP WG 6.1 International Conference on Formal Techniques for Distributed Objects, Components, and Systems, FORTE 2019, held in Copenhagen, Denmark, in June 2019, as part of the 14th International Federated Conference on Distributed Computing Techniques, DisCoTec 2019. The 15 full and 3 short papers presented were carefully reviewed and selected from 42 submissions. The conference is dedicated to fundamental research on theory, models, tools, and applications for distributed systems.

Defining organs at risk is a crucial task for radiation oncologists when aiming to optimize the benefit of radiation therapy, with delivery of the maximum dose to the tumor volume while sparing healthy tissues. This book will prove an invaluable guide to the delineation of organs at risk of toxicity in patients undergoing radiotherapy. The first and second sections address the anatomy of organs at risk, discuss the pathophysiology of radiation-induced damage, and present dose constraints and methods for target volume delineation. The third section is devoted to the radiological anatomy of organs at risk as seen on typical radiotherapy planning CT scans, with a view to assisting the radiation oncologist to recognize and delineate these organs for each anatomical region – head and neck, mediastinum, abdomen, and pelvis. The book is intended both for young radiation oncologists still in training and for their senior colleagues wishing to reduce intra-institutional variations in practice and thereby to standardize the definition of clinical target volumes. ​

This book, first published in 1987, looks at the processes and spread of social innovation: the mechanisms of this innovation are rooted in the conflict that minorities are capable of creating in others and introducing into the social system. These innovations give rise to rejection, discrimination and denial of the minority group. However, minority ideas take root and gradually new norms replace the old ones. Despite the denial, therefore, the marginal standpoint of minority groups can have an impact on the belief systems and behaviour patterns of other individuals. This book proposes a psychosociological explanation of these individual and collective phenomena by articulating the underlying identification games and cognitive activities. It throws fresh light not only on minority influence, but also on major themes of social psychology, especially theories of intergroup conflict, persuasion and attitude change. Based upon a series of experiments which have been developed and refined for the 1991 English edition, this is a rigourous and valuable contribution to the study of minority influence on social processes.

Organisms are constantly being bombarded by stimuli in their envi ronment (and also by internal stimuli), and a common way of responding is by movement. This is an aspect of irritability, or excitability, or behaviour. Response to stimuli by movement is found in all organisms: it represents one of the universalities of biology. Yet at the molecular level it is one of the least understood of biological phenomena. Micro-organisms are no exception. If motile, they respond to stimuli by active movement (taxis); if sessile, they respond by growth movements (tropisms). Responses by movement are known among micro-organisms to such stimuli as chemicals, electric current, gravity, light, temperature, touch, and vibrations. The behaviour of micro-organisms is an exciting subject, first of all for its own sake, but in addition because it may reveal facts and concepts that are applicable to understanding behaviour in more complicated organisms (even us) and because it may, help to understand the movement of cells and tissues during differentiation and development of higher plants and animals.

Cartagena of Indias, Columbia, September 13-19, 1998

This anthology addresses the role of postsecondary institutional structures and policy in shaping the tenure-track process for Chicana and Latina faculty in higher education. Each chapter offers first-person narratives of survival in the academy employing critical theoretical contributions and qualitative empirical research. Major topics included are the importance of early socialization, intergenerational mentorship, culturally relevant faculty programming, and institutional challenges and support structures. The aim of this volume is to highlight practical and policy implications and interventions for scholars, academics, and institutions to facilitate tenure and promotion for women faculty of color.

This edited book addresses the issues of gun trafficking and gun violence across different regions of the world, including the Americas, Africa, Asia, Europe and Oceania. It seeks to identify global key trends on gun trafficking and related violence and discuss different enforcement measures. Each chapter is written by teams of distinguished academics and/or experienced practitioners to include practitioner insights and policy proposals on issues related to gun violence and gun trafficking. Chapters offer an overview of violence and recent gun control debates in the regions, enumerate challenges, provide lessons learnt, and recommend policy solutions. An overview of the global small arms trade is provided at the beginning alongside a comparative analysis of common challenges and significant differences across the regions. This book speaks to those in Criminology, International Relations, Public Policy, International Security, Public health and Law, and to civil society organizations, think tanks, research centers, policy analysts and policy makers involved in gun control debates.

Updated with details on the newest therapies and sporting a new full-color design, this latest edition of Radiation Oncology: Management Decisions continues to offer comprehensive guidance for residents as well as radiation oncologists already in professional practice. You'll discover the latest treatment plans for numerous cancer sites and tumor types, including the mouth and sinus, gastrointestinal areas, lungs, bones, and blood. Concise, easy-to-read material you can use in a clinical setting immediately with patients! Combines comprehensive overviews of basic concepts with the latest radiologic treatment regimens for a wide variety of tumor types and cancer sites. Now in full color! Bursting with hundreds of illustrations, figures, and images to illuminate visually important and state-of-the-art techniques. Heavily bulleted content format and to-the-point writing style makes content easy to digest and use with patients quickly. Chapters that address tumor- or site-specific treatments cover screening, assessment, staging, therapeutic developments, and other key information. Features an up-to-date list of commonly prescribed drugs-streamlined for easier reading-and coverage of the latest pain management and palliative treatments. Enhance Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

This well-received book, now in its fifth edition, is unique in providing a detailed examination of the technological basis of radiation therapy. Another unique feature is that the chapters are jointly written by North American and European authors. This considerably broadens the book's contents and increases its applicability in daily practice throughout the world. The book is divided into two sections. The first section covers basic concepts in treatment planning and explains the various approaches to radiation therapy, such as intensity-modulated radiation therapy, tomotherapy, stereotactic radiotherapy, and high and low dose rate brachytherapy. The second discusses in depth the practical clinical applications of the different radiation therapy techniques in a wide range of cancer sites. All chapters have been written by leaders in the field. This book will serve to instruct and acquaint teachers, students, and practitioners with the basic technological factors and approaches in radiation therapy.

Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for neuroprotection. While stroke and many other brain injuries are not predictable, in some populations (e.g., metabolic syndrome, patients undergoing carotid endarterectomy, aneurysm clipping, or with recent TIAs) the risk for stroke is identifiable and significant, and preconditioning may represent a useful strategy for neuroprotection. For unpredictable injuries, post-conditioning the brain - or inducing endogenous protective mechanisms after the initial injury - can also abrogate the extent of injury. Finally, remote pre- and post-conditioning methods have been developed in animals, and are now being tested in clinical trials, wherein a brief, noninjurious stress to a noncerebral tissue (i.e., skeletal muscle) can provide protection to the CNS and thereby allows clinicians the opportunity to circumvent concerns regarding the direct preconditioning of neurological tissues.

In this expansive and contemplative history of Cuba, Louis A. Perez Jr. argues that the country's memory of the past served to transform its unfinished nineteenth-century liberation project into a twentieth-century revolutionary metaphysics. The ideal of national sovereignty that was anticipated as the outcome of Spain's defeat in 1898 was heavily compromised by the U.S. military intervention that immediately followed. To many Cubans it seemed almost as if the new nation had been overtaken by another country's history. Memory of thwarted independence and aggrievement - of the promise of sovereignty ever receding into the future - contributed to the development in the early republic of a political culture shaped by aspirations to fulfill the nineteenth-century promise of liberation, and it was central to the claim of the revolution of 1959 as the triumph of history. In this capstone book, Perez discerns in the Cuban past the promise that decisively shaped the character of Cuban nationality.