Protease inhibitors (PIs) are widely distributed in plants and animals, and have a variety of functions, which include preventing digestion of seeds by insects and modifying blood clotting in animals. After it was noted that synthetic and natural inhibitors suppress two-stage carcinogenesis and breast cancer, extensive work investigating PIs as chemopreventive agents was started. PIs are unique in that they interfere with cancer development in a variety of ways, including suppression of oxygen radicals, oncogenes, and metastases. Epidemiologic evidence supports their prevention of major human cancers in populations that consume foods containing them. Their supervised use in humans is on the threshold of development. The epidemiologic discovery of the importance of lentils and other seeds rich in PIs in preventing many human cancers allowed us to look at the action of PIs as chemopreventive agents, as reviewed in Chapter I (Fontham and Correa). Chapter 2 (Kennedy) discusses the role of natural PIs (e. g. , the Bowman-Birk inhibitor) as anticarcinogens and the possible limitations of their use. In Chapter 3 (Kennedy), the transformation of C3HI lOTlh cells caused by carcinogens and promoters is shown to be suppressed by PIs. Bowman (Chapter 4) relates the discovery of inhibitors in soybeans that are distinct from the Kunitz inhibitor, and the occurrence of a similar inhibitor in peanuts and other legumes. Chapter 5 (Birk) is an overview of PIs of plant origin and their role in human nutrition.

The Making of the Modern Law: Legal Treatises, 1800-1926 includes over 20,000 analytical, theoretical and practical works on American and British Law. It includes the writings of major legal theorists, including Sir Edward Coke, Sir William Blackstone, James Fitzjames Stephen, Frederic William Maitland, John Marshall, Joseph Story, Oliver Wendell Holmes, Jr. and Roscoe Pound, among others. Legal Treatises includes casebooks, local practice manuals, form books, works for lay readers, pamphlets, letters, speeches and other works of the most influential writers of their time. It is of great value to researchers of domestic and international law, government and politics, legal history, business and economics, criminology and much more.++++The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: ++++Yale Law School LibraryCTRG98-B3010Includes indexes.London: Stevens and Sons, 1924. xix, 200 p.; 22 cm

Histories of American Physical Anthropology in the Twentieth Century chronicles the history of physical anthropology_or, as it is now known, biological anthropology_from its professional origins in the late 1800 up to its modern transformation in the late 1900s. In this edited volume, 13 contributors trace the development of people, ideas, traditions, and organizations that contributed to the advancement of this branch of anthropology that focuses today on human variation and human evolution. Designed for upper level undergraduate students, graduate students, and professional biological anthropologists, this book provides a brief and accessible history of the biobehavioral side of anthropology in America.

Histories of American Physical Anthropology in the Twentieth Century chronicles the history of physical anthropology or, as it is now known, biological anthropology from its professional origins in the late 1800 up to its modern transformation in the late 1900s. In this edited volume, 13 contributors trace the development of people, ideas, traditions, and organizations that contributed to the advancement of this branch of anthropology that focuses today on human variation and human evolution. Designed for upper level undergraduate students, graduate students, and professional biological anthropologists, this book provides a brief and accessible history of the biobehavioral side of anthropology in America."