Incorporating the most important advances in the fast-growing field of cancer biology, the text maintains all of its hallmark features. It is admired by students, instructors, researchers and clinicians around the world for its clear writing, extensive full-colour art programme and numerous pedagogical features.

The scope of these chapters reflects the strong influence that Sandra Wood Scarr's scholarship-her empirical research and theoretical contributions-has had on what we know about experience and development via the lens of the psychological sciences, especially the fields of developmental psychology, behavior genetics, early education and child care.

Incorporating the most important advances in the rapidly-evolving field of cancer biology, this book remains the defining course text on its subject. Students, instructors, researchers, and clinicians the world over admire its authoritative content, clear explanations, extensive full-color art program, and pedagogical features that promote a deep conceptual understanding of the science through the lens of fascinating tales of scientific discovery.

This 32nd volume of the Minnesota Symposium on Child Psychology celebrates the 75th anniversary of the University of Minnesota's Institute of Child Development. All eight essays are devoted to developmental science, its history, and current status. Taken together, the chapters in this book show how the history of science connects past and future, how it gives the individual investigator an identity and sense of purpose, how contemporary studies occur within larger traditions, and how institutions like the Institute of Child Development, constitute cultural traditions of their own. Collectively, these essays show that the past explains a great deal--whether we want to know about the processes through which the child acquires symbolic thought or whether we want to know how and why, during the last century, a few enduring centers were established for the scientific study of children and adolescents. Reading these essays, one obtains a sense of how the past becomes evidence, how it forms models for the way we think, and how intellectual challenges arise.

The scope of these chapters reflects the strong influence that Sandra Wood Scarr s scholarship her empirical research and theoretical contributions has had on what we know about experience and development via the lens of the psychological sciences, especially the fields of developmental psychology, behavior genetics, early education and child care.

Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same.Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute with extensive original reporting, including more than thirty-five interviews to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it.The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers."

Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancer's occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem of the body's tissues. His theory ties cancer's progression, or lack thereof, to evolved strategies to maximize reproductive success. Through natural selection, humans evolved genetic programs to maintain bodily health for as long as necessary to increase the odds of passing on our genes-but not much longer. These mechanisms engender a tissue environment that favors normal stem cells over precancerous ones. Healthy tissues thwart cancer cells' ability to outcompete their precancerous rivals. But as our tissues age or accumulate damage from exposures such as smoking, normal stem cells find themselves less optimized to their ecosystem. Cancer-causing mutations can now help cells adapt to these altered tissue environments, and thus outcompete normal cells. Just as changes in a species' habitat favor the evolution of new species, changes in tissue environments favor the growth of cancerous cells. DeGregori's perspective goes far in explaining who gets cancer, when it appears, and why. While we cannot avoid mutations, it may be possible to sustain our tissues' natural and effective system of defense, even in the face of aging or harmful exposures. For those interested in learning how cancers arise within the human body, the insights in Adaptive Oncogenesis offer a compelling perspective.

Including practical advice on how to conduct a stress audit and how to target stress 'hot spots' within an organization, Organizational Stress Management provides a fresh strategic model for the manager concerned with the negative effects stress can have both on company performance and the quality of life of individuals at work.

Is it possible to measure the human spirit? Whether we could or should, at some point would we have to recognize that what we seek is magical in some way? Or would we come to learn that the qualities of true grit and positive thinking, or the ability to smile in the face of seemingly insurmountable odds, are those upon which any of us can call in turbulent times? The continuity of human existence means we do not go empty handed into the darker hours, for the attributes of courage and perseverance lie ready in our emotional armory. Times which echo to the sound of crashing financial markets are here, and while their resonance is both deafening and frightening, history tells us that such storms will seem like turbulence when viewed in retrospect. Our quest is how to survive them to be able to take such a privileged view. Collectively the human spirit has so far proved equal to the task and this book seeks to chart the psychological sources of challenge and inspiration for individuals, families and organizations. Stress is undoubtedly one of the major workrelated illnesses and is even more common in times of economic uncertainty and downturn. In this new and innovative book Ashley Weinberg and Cary Cooper asses the psychological challenges created by instability and uncertainty and provide a survival toolkit that shows you how to combat stress in your own lives.

Stress isundoubtedly one of the major work-related illness and is even more likely in times of economic uncertainty and downturn. Theauthors assess the psychological challenges created by instability and uncertainty and provide a survival toolkit that shows the reader how to combat stress in their own lives.

Including practical advice on how to conduct a stress audit and how to target stress 'hot spots' within an organization, "Organizational Stress Management" provides a fresh strategic model for the manager concerned with the negative effects stress can have both on company performance and the quality of life of individuals at work.

Thoroughly updated and incorporating the most important advances in the fast-growing field of cancer biology, The Biology of Cancer, Second Edition, maintains all of its hallmark features admired by students, instructors, researchers, and clinicians around the world.

The Biology of Cancer is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The principles of cancer biology are presented in an organized, cogent, and in-depth manner. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology.

The new Second Edition has been comprehensively revised and updated to include major advances in cancer biology over the past six years. Updates include current information on:

• The tumor microenvironment
• Metastatic dissemination
• Tumor immunology
• Cancer stem cells
• The epithelial-mesenchymal transition
• Multi-step tumorigenesis
• Invasion and metastasis
• Mutation of cancer cell genomes
• Greatly expanded treatment of traditional therapy
• Epigenetic contributions
• MicroRNA involvement
• The Warburg effect

Besides its value as a textbook, The Biology of Cancer is a useful reference for individuals working in biomedical laboratories and for clinical professionals.

Every copy of the book comes with an updated "Pathways in Human Cancer" poster and a DVD-ROM containing the book s art program, a greatly expanded selection of movies, audio file mini-lectures, Supplementary Sidebars, and a Media Guide."

A Critical Resource with Information You Won't Find Anywhere Else.

Dentists of all specialties prescribe drugs for their patients, from pain medications to sedatives to antibiotics, and know all too well that making an evidenced-based decision on which drug to prescribe is more than just looking up a drug on the computer or PDA and requires more comprehensive consideration than the current drug reference books offer.For example, should an antibiotic be prescribed for implant placement or for sinus augmentation procedures? If so, what antibiotic is recommended (backed up with references), when should it be started, and for how long? Which is the antibiotic of choice for an odontogenic infection and how do you know if that antibiotic is working?Improve Your Decision Making with this Essential Guide."The Dentist's Drug and Prescription Guide" is the only book to offer comprehensive coverage of this topic and has quickly become the go-to reference for dental students, general dentists, periodontists, oral surgeons, dental hygienists.

Written for dental professionals seeking quick advice on prescribing medications for their patients, the book offers: An easy-to-read question-and-answer format, the text describes evidenced-based pharmacologic therapy with current and up-to-date references regarding adjunctive pharmacologic treatment of the dental patientEasy-to-follow drug tables that summarize the main pharmacologic features of the different disciplines, including periodontics, implantology, oral surgery, and endodontics, with recommendations for pharmacologic treatment with periodontal and implant surgery as well as treatment of periodontal diseases, dental pain, and infectionDetailed strategies to manage and prevent drug interactions in the dental practiceInstructions and guidelines for the patient on how to take the drugs (e.g., to avoid GI upset when taking antibiotics acidophilus or yogurt can be taken).Plus, sample prescriptions, coverage of proper documentation in the patient's chart, and more

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If you are in information technology and you have the ambition and inborn drive to be among the very best--or if you need to engage an IT consultant and want to know how to recognize the best--this book is for you. In most fields, a consultant is an expert who provides advice and guidance. Implementing the advice is up to the client. In information technology, the term "computer consultant" covers a wider range. Business expertise is frequently an even more critical element of the delivery than technical expertise. Because implementation of the consultant's advice may require highly specialized skills, the consultant may offer to manage a team to perform some or all of the IT work that needs to be done, or may even offer supplemental staff for a client. But at the other end of the spectrum, some people call themselves computer consultants when their work is exclusively technical, such as programming or network design. Exactly what is a consultant in the field of information technology? What's the different between an ordinary computer consultant and one who stands out above the crowd? If you want to be an exemplary, top of the line consultant in the IT field, what do you need to do? This book addresses these questions. Contributors include Jerry Weinberg, who is practically legendary for his keen insight, and Steve Epner, founder of the Independent Computer Consultants Association. Each chapter explores a different aspect of what it takes to be a truly excellent computer consultant and provide the highest levels of value and service for clients.

Systematic observation is essential for educators to evaluate properly the effectiveness of curricula and to address the problems of individual students. This volume emphasizes early childhood settings, and focuses on those skills that enable the observer to make appropriate, valid inferences and to arrive at decisions based on objective observation data gathered in natural learning environments and diverse educational settings. The edition includes new focuses on: procedures for observing environmental factors that affect learning and behaviour; the importance of understanding the cultural and linguistic characteristics of children's learning environments; the key role of observation in the assessment process; the forms of observation, with illustrative examples; and the exploration of reliability, sampling behaviour, recording formats, summarizing observational outcomes and validity. Using photographs, sample worksheets, a simple format and straightforward language, the authors cite real-life examples from early childhood that can be applied to a variety of classroom experiences.