0
Your cart

Your cart is empty

Browse All Departments
  • All Departments
Price
  • R1,000 - R2,500 (2)
  • -
Status
Brand

Showing 1 - 2 of 2 matches in All Departments

Advances in Medicinal Chemistry, Volume 5 (Hardcover): A.B. Reitz, S.L. Dax Advances in Medicinal Chemistry, Volume 5 (Hardcover)
A.B. Reitz, S.L. Dax
R1,923 Discovery Miles 19 230 Ships in 12 - 17 working days

Volume 5 of "Advances in Medicinal Chemistry" contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.

Advances in Medicinal Chemistry, Volume 4 (Hardcover): B.E. Maryanoff, A.B. Reitz Advances in Medicinal Chemistry, Volume 4 (Hardcover)
B.E. Maryanoff, A.B. Reitz
R2,016 Discovery Miles 20 160 Ships in 12 - 17 working days

Volume 4 of "Advances in Medicinal Chemistry" is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol(r) (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.

Free Delivery
Pinterest Twitter Facebook Google+
You may like...
The Bourne Evolution
Brian Freeman Paperback  (1)
R460 R378 Discovery Miles 3 780
Breekpunt
Marie Lotz Paperback R340 R249 Discovery Miles 2 490
The Survivors
Jane Harper Paperback R441 R365 Discovery Miles 3 650
Witness 8
Steve Cavanagh Paperback R415 R280 Discovery Miles 2 800
Act Of Oblivion
Robert Harris Paperback R371 Discovery Miles 3 710
If I Survive You
Jonathan Escoffery Paperback R295 R236 Discovery Miles 2 360
The Coven
Lizzie Fry Paperback R433 R357 Discovery Miles 3 570
Fire On The Horizon
Wilbur Smith, Imogen Robertson Hardcover R385 R260 Discovery Miles 2 600
The Cuban Affair
Nelson DeMille Paperback  (1)
R186 Discovery Miles 1 860
The Therapist
Helene Flood Paperback R398 R327 Discovery Miles 3 270

 

Partners