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Application of recent advances, such as non-equilibrium
thermodynamics, the maintenance concept and the material balancing
method, to the description, of microbial growth has suggested new
experimental approaches which have yielded a wealth of data. These
data have been used to develop mathematical models of microbial
growth and metabolism, and the models have made it possible to
direct the metabolism of a microorganism in such a way that more of
a certain desired product is made. While a full quantitative
description of all aspects of microbial growth and metabolism is
till remote, the new approaches are opening up large areas of new
potential -- it is now possible, for instance, to deal with
individual cells in a population and with quantitative aspects of
product formation and optimisation. Microbiologists, biochemists
and physiologists will find this an invaluable update on a field of
great promise.
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