This text discusses the applications and optimization of emerging smart technologies in the field of healthcare. It further explains different modeling scenarios of the latest technologies in the health care system and compare the results to better understand the nature and progress of the disease in the human body that leads to early diagnosis and better cure of disease and treatment with the help of distributed technology. Covers the implementation models using technologies such as artificial intelligence, machine learning, deep learning with distributed systems for better diagnosis and treatment of diseases. Gives in-depth review of the technological advancements like advanced sensing technologies like Plasmonic sensors, usage of RFIDs and electronic diagnostic tools in the field of healthcare engineering Discusses possibilities of augmented reality and virtual reality interventions for providing unique solutions in medical science, clinical research, psychology, and neurological disorders Highlights the future challenges and risks involved in the application of smart technologies like Cloud computing, fog computing, IOT and distributed computing in heathcare. Confers to utilize the AI and ML and associated aids in healthcare sectors in the post Covid 19 to revitalize the medical set up Contributions included in the book will motivate the technological developers and researchers to develop new algorithms and protocols in healthcare field. It will serve as the vast place for knowledge regarding healthcare health care delivery, health care management, health care in governance, and health monitoring approaches using distributed environments. It will serve as an ideal reference text for graduate students and researchers in diverse engineering fields including electrical, electronics and communication, computer, and biomedical.