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Asymmetric Synthesis of Natural Products Fully updated learning
resource covering the concept of using natural product chemistry
for strategies in asymmetric synthesis The third edition of
Asymmetric Synthesis of Natural Products introduces students to the
rapidly growing field of natural products in organic chemistry,
discussing the practical, mainly pharmacological, importance of
selected compounds and emphasizing the target-oriented approach of
organic synthesis which is key in industrial strategies. To aid in
reader comprehension, the text includes key references and an Index
of Compounds. The textbook is based on two lecture courses
(Asymmetric Synthesis & Asymmetric Synthesis of Natural
Products), which the author has delivered more than 50 times over
the past 20 years in Finland, the UK, Italy, and Greece. This third
edition is fully updated from the earlier versions (published by
Wiley in 1993 and 2012). The importance of natural products as
truly renewable raw materials in sustainable chemistry and circular
economy is illustrated through applications of e.g.
organocatalysis, organometallic catalysis, and biocatalysis. The
contents consist of traditional text supplemented with
illustrations (such as chemical drawings and structural formulae).
Three dimensional aspects are also discussed with the use of 3D
renderings of structures for both reaction mechanisms (molecular
modeling) and crystallographic data. Sample topics covered in the
textbook include: The foundations of asymmetric synthesis,
including the theory and applications of individual asymmetric
reactions Sustainable development, the circular economy, and use of
renewable raw materials that have become prominent in many fields
of science and technology Various natural product classes,
including carbohydrates, amino acids, peptides, proteins,
nucleosides, nucleotides, nucleic acids, and polyketides The
properties of these natural product classes, including their
structures, biosynthesis, and interrelationships, as well as
examples of asymmetric syntheses and the practical value of these
compounds Asymmetric Synthesis of Natural Products is a
comprehensive, authoritative, and up-to-date learning resource on
the subject for advanced level undergraduate or early-stage
graduate students. It is also useful for specialists already
working in synthesis who wish to learn about asymmetric synthesis.
Saponins are complex molecules made up of sugars linked to a
triterpenoid or a steroid or a steroidal alkaloid. These natural
products are attracting much attention in recent years because of
the host of biological activities they exhibit. The diversity of
structural features, the challenges of isolation because of their
occurrence as complex mixtures, the pharmacological and biological
activities still to be discovered, and the prospect of
commercialization - these all are driving the study of saponins.
Triterpenoid saponins are dominating constituents of this class and
occur widely throughout the plant kingdom including some human
foods e. g. beans, spinach, tomatoes, and potatoes, and animal feed
e. g. alfalfa and clover. Saponins were initially a rather
neglected. area of research primarily because of great difficulties
in their isolation and characterization. With the advent of more
sophisticated methods of isolation and structure elucidation
through the last two decades, there has been increased interest in
these natural products. Besides structure determination, research
activities are now moving forward to clarify structure-activity
relationships. Our previous reviews on triterpenoid saponins (l, 2)
covered literature from 1979 to mid-1989. The literature on
triterpenoid saponins up to 1988 has also been covered by two
reviews by HILLER et at. (3, 4). This review incorporates newer
trends in isolation and structure determination of triterpenoid
saponins, new triterpenoid saponins isolated and biological
properties of these products reported during the period late
1989-mid 1996. 2."
Asymmetric Synthesis of Natural Products Ari Koskinen Department of
Chemistry, University of Oulu, Finland Natural product synthesis
has played a key role in the development of many synthetic methods
and will continue to do so in the future. Many recent advances in
such diverse fields as immunology, cellular biology and materials
science have been achieved through the synthetic chemist's ability
to construct often very complicated structures in one enantiomeric
form. This book introduces the student to this rapidly growing
field of organic chemistry. The first three chapters present the
foundations of asymmetric synthesis, with Chapter 3 describing, in
concise but clear rationalizations, the reasons for the major
asymmetric transformations. Chapters 4 to 10 cover individual
classes of natural products; their structures, biosynthesis and
interrelationships as well as examples of asymmetric syntheses and
the practical value of these compounds.
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