This book constitutes selected papers presented at the First International Conference on ICT for Health, Accessibility and Wellbeing, IHAW 2021, held in Larnaca, Cyprus, in November 2021. The 12 full papers and 7 short papers were thoroughly reviewed and selected from 36 submissions. One invited paper was also included in this volume. The papers are organized in topical sections on active aging; assistive devices and systems; brain functions support and mHealth; brain functions support and oncology; ICT and wellbeing.