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Due to sensitive molecular biological techniques, our understanding
of chromosomal aberrations is steadily increasing. Provided here is
a review of basic and applied aspects of the field. Chromosome
structure, induction of DNA lesions by different clastogenic agents
and their repair, induction of aberrations by agents which affect
specific sequences in the DNA, and factors affecting induction and
yield of chromosomal aberrations are covered.
Further, topics such as automation of aberration scoring, problems
associated with using chromosomal aberrations and micronuclei in
population monitoring and the importance of chromosomal aberration
assays in mutagenicity testing of chemicals are included.
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