This manuscript provides information about immunotoxico-pathology in arsenic intoxicated broiler chicks and were challenged with Newcastle Disease. This information is useful in places where arsenic is higher in ground water than permissible levels and especially poultry birds are reared. Information generated in this manuscript can also be applied on other species present as natural habitant in the vicinity or coming to site where arsenic is a problem. One can realize what type of immunotoxic effects would be occurring. If these birds are exposed to Newcastle disease, then what world the scenario of immunopathology in these birds.