Guest Editor Adre du Plessis addresses Neonatal Neurology in this issue of Clinics in Perinatology, a companion to his September 2009 issue on Fetal Neurology. Mechanisms and management of acute brain injury is reviewed, including articles on Systemic and cerebral transitional hemodynamics in premature infants, Hypoxic-ischemic brain injury in the term infant, Neuroprotection in the newborn infant, Intracranial hemorrhage in the premature and term newborn, Infection-inflammatory mechanisms of brain injury in the newborn, Neonatal stroke, and Neonatal seizures. Next, Neurodiagnostic advances for the newborn infant is explored, with articles covering, Advanced brain MRI techniques, Advances in Near Infrared Spectroscopy, and Bedside electrocortical monitoring. The issue closes with a section devoted to Longterm neurologic outcome: Mechanisms of dysfunction and recovery, with articles on Longterm outcome in premature infants, Mechanisms of Cerebral Plasticity, The longterm effects of neonatal seizures, Constraint-induced therapy: Plasticity in practice, and Neonatal brain injury and autistic spectrum disorders in survivors.

Fetal Neurology is covered in this issue of Clinics in Perinatology, guest edited by Dr. Adre du Plessis. The genetic basis of normal brain development and its disorders is explored, including reviews on the prosencephalon, the cerebral cortex, and the cerebellum. Next, normal and abnormal circulatory support of the fetal brain is covered, with articles on normal fetal cerebral substrate supply, disorders of placental circulation and the fetal brain, and disorders of fetal circulation and the fetal brain. Toxic-metabolic causes of disturbed brain development is reviewed, including articles on primary disorders of metabolism and disturbed fetal brain development and maternal drug abuse and impaired fetal brain development. Next, a section on infectious-inflammatory causes of disturbed brain development includes articles on fetal viral infections and impaired brain development and fetal inflammation and impaired brain development. A section on disorders of labor and delivery covers fetal hypoxia insults and patterns of brain injury, the fetal heart rate response to hypoxia, and non-asphyxial hypoxic-ischemic brain injury during prolonged labor. The issue closes with a section on advances in fetal neurodiagnostic testing, including reviews on imaging the fetal brain, quantitative fetal heart rate techniques, and fetal magnetoencephalography for assessment of fetal neurologic function.

The 5th edition of this indispensable resource captures the latest insights in neonatal neurology in a totally engaging, readable manner. World authority Dr. Joseph Volpe has completely revised his masterwork from cover to cover, describing everything from the most up-to-the-minute discoveries in genetics through the latest advances in the diagnosis and management of neurologic disorders. He delivers all the clinical guidance you need to provide today's most effective care for neonates with neurological conditions. Provides comprehensive coverage of neonatal neurology, solely written by the field's founding expert, Dr. Joseph Volpe - for a masterful, cohesive source of answers to any question that arises in your practice. Focuses on clinical evaluation and management, while also examining the many scientific and technological advances that are revolutionizing neonatal neurology. Organizes disease-focused chapters by affected body region for ease of reference. Features a brand new, full-color design with hundreds of new figures, tables, algorithms, and micrographs. Includes two entirely new chapters: Neurodevelopmental Follow-Up and Stroke in the Newborn; a new section on Neonatal Seizures; and an extensively expanded section on Hypoxic-Ischemia and Other Disorders. Showcases the experience and knowledge of a new editorial team, led by Dr. Joseph Volpe and Dr. Terrie E. Inder, Chair of the Department of Pediatric Newborn Medicine at Brigham and Women's Hospital, all of whom bring a wealth of insight to this classic text. Offers comprehensive updates from cover to cover to reflect all of the latest information regarding the development of the neural tube; prosencephalic development; congenital hydrocephalus; cerebellar hemorrhage; neuromuscular disorders and genetic testing; and much more. Uses an improved organization to enhance navigation. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.