The last decades have shown a remarkable increase in the number of heavy rains, typhoons and earthquakes. These natural phenomena are the main causes for geohazards. As a result the mitigation of geohazards has become a major research topic in geotechnical engineering, and in recent years simulation-based predictions and monitoring tools have been developed to enquire the mechanisms underlying geohazards. This book is a comprehensive overview of these developments, and will be of interest to engineers, researchers, students in Civil and Environmental Engineering.

Computer Methods and Recent Advances in Geomechanics contains the proceedings (abstracts book 472 pages + full paper USB-drive 2052 pages) of the 14th International Conference of the International Association for Computer Methods and Advances in Geomechanics (Kyoto, Japan, 22-25 September, 2014). The contributions cover computer methods, material modeling and testing, applications to a wide range of geomechanical issues, and recent advances in various areas that may not necessarily involve computer methods, including: - Development and usage of new materials; - Constitutive modeling of materials including deformation, damage and failure; - Verification of existing and new constitutive models; - Micro-macro correlations of material response including non-destructive testing; - New techniques for material and site characterization; - Computer-aided engineering and expert system; - Innovative construction using new materials and computer methods; - Design and rehabilitation of infrastructure; - Use of system and optimization procedures, and - Remote sensing. Computer Methods and Recent Advances in Geomechanics will be of interest to researchers and engineers involved in geotechnical mechanics and geo-engineering.

The last decades have shown a remarkable increase in the number of heavy rains, typhoons and earthquakes. These natural phenomena are the main causes for geohazards. As a result the mitigation of geohazards has become a major research topic in geotechnical engineering, and in recent years simulation-based predictions and monitoring tools have been developed to enquire the mechanisms underlying geohazards. This book is a comprehensive overview of these developments, and will be of interest to engineers, researchers, students in Civil and Environmental Engineering.

New Antisense Strategies: Chemical Synthesis of RNA Oligomers, by Junichi Yano und Gerald E. Smyth Development and Modification of Decoy Oligodeoxynucleotides for Clinical Application, by Mariana Kiomy Osako, Hironori Nakagami und Ryuichi Morishita Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides, by Ekambar R. Kandimalla und Sudhir Agrawal Delivery of Nucleic Acid Drugs, by Yan Lee und Kazunori Kataoka Aptamer: Biology to Applications, by Yoshikazu Nakamura Development and Clinical Applications of Nucleic Acid Therapeutics, by Veenu Aishwarya, Anna Kalota und Alan M. Gewirtz

New Antisense Strategies: Chemical Synthesis of RNA Oligomers, by Junichi Yano und Gerald E. Smyth Development and Modification of Decoy Oligodeoxynucleotides for Clinical Application, by Mariana Kiomy Osako, Hironori Nakagami und Ryuichi Morishita Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides, by Ekambar R. Kandimalla und Sudhir Agrawal Delivery of Nucleic Acid Drugs, by Yan Lee und Kazunori Kataoka Aptamer: Biology to Applications, by Yoshikazu Nakamura Development and Clinical Applications of Nucleic Acid Therapeutics, by Veenu Aishwarya, Anna Kalota und Alan M. Gewirtz