As little as two decades ago, deliberately injecting botulinum toxin into patients would have seemed foolhardy at best and criminal at worst. The increased clinical use of botulinum toxins has expanded the body of knowledge available on the structure and function of these proteins. This knowledge can be applied to topics as varied as therapies based on the endopeptidase activity of the toxins, vaccine development, protection against botulism, and vectors for neuronal drug delivery. Based on recent scientific and clinical information from top international authorities, Treatments from Toxins: The Therapeutic Potential of Clostridial Neurotoxins reviews the status of current research and development and identifies significant developments. Drawing on their vast experience in this field, the editors present the basic background of the bacteriology and genetics of the neurotoxigenic clostridia, a history of the discovery of the neurotoxins, and an overview of the tetanus and botulism diseases. The chapters detailing common medical applications of the toxins cover side effects and novel uses, including neuronal drug delivery strategies, and provide a fresh look at what can still be achieved. They also explore the toxins as potential threat agents and the advent of the therapeutic use of botulinum toxins. Highlighting the pitfalls, successes, and challenges that exist when engineering complex proteins, the book brings together the clinical and theoretical worlds. It presents a broad overview of the current status of botulinum research and its clinical applications.

Lady Beatrice Musgrave and Vincent Crabbe set off to explore Wales on horseback, accompanied by a gig and driver. Beatrice wants to see dragons and indeed does so more than once but, as well, the pair have other adventures -- defeating witches, rescuing enchanted sisters and helping people in distress.

This book is an attempt to explain or simplify some of the difficult passages in the Bible that puzzle readers who desire to grasp the truth of what is being said, for example, what does this mean - "in Jesus' Name"? Who were the two Adams and who was Eve? Male superiority according to St. Paul The 'begats' - why bother? If you desire to know more about Jesus, Himself, then read "the character of Jesus in His own words Have you ever wondered about the spiritual value of music? Two chapters cover this important subject. So much has already been written about the Creation Story, but you will certainly find some interesting information which will help you understand these controversial biblical passages. In a lighter vein, the "Church Year" is explained, with the various High and Holy Days that we celebrate. New Year and some thoughts on St. Patrick and his inspiration and legacy are included. For those who belong to a Bible study group a few short questions for discussion are included. Some are easy, but others are more difficult However, the book can be read straight through by the reader. The writer seeks to show people that God's message is simple and easy to understand. By accepting it into our hearts and minds we find ourselves accepted into His kingdom with everlasting joy and gladness. So, dear Reader, read on and receive God's blessing.