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The cutting-edge techniques detailed here include those that are
particularly popular in multidisciplinary neuroscience research.
There are readily reproducible methods for establishing neural cell
cultures, measuring enzymes and their inhibitors, and using
quantitative autoradiography to study monoamine uptake sites and
receptors in the brain. Additional methods cover the use of flow
cytometry to study developmental neurobiology, applications of
magnetic resonance spectroscopy (MRS) to human brain metabolism,
and the study of drug metabolism. Together with its companion
volumes, In Vivo Neuromethods and In Vitro Neurochemical
Techniques, all three cutting-edge works will prove exceptionally
useful to those basic and clinical neuroscientists who want to
expand the range of their current research or develop competence in
complementary methods.
A superb collection of time-tested, key techniques for
investigating nervous system function, as well as the actions of
drugs on the nervous system. The methods range from authoritative
treatment of such well-established techniques as recording
electrical activity in the brain, to practical coverage of
state-of-the-art methods, including neural transplantation and
antisense technology. The techniques described are particularly
suitable for studying the mechanisms of action of psychotropic
drugs and drugs of abuse, as well as the etiology and
pharmacotherapy of neuropsychiatric diseases and neurodegenerative
disorders. Several of the methods detailed are highly useful in
screening potential drugs for the treatment of depression, anxiety
disorders, schizophrenia, and Parkinson's and Alzheimer's disease.
In Vitro Neurochemical Techniques is one of three volumes that rep-
sent an update of the original Volume 1 of Neuromefkods, General
Neu- chemical Techniques The expansion to three volumes was
necessitated by the rapidly increasing number of techniques being
used by neuroscrentists and the general tendency of neuroscience
research to become more multidisciplrnary and collaborative in
recent years. The two companion volumes are concerned primarily
with In Vwo Neurometkods in one case, and with Cell Neurobiology
Techniques in the other case. Even with three volumes, the coverage
of General Neuvometkods is obviously not exhaustive. We have
attempted to cover those techniques that seem particularly popular
in multidisciplinary neuroscience research. Though some important
techniques may have been omitted, we believe that most of these
have been covered in detail in other recent volumes of Neurometkods
or will be the subjects of upcommg volumes The editors anticipate
that these volumes will prove unusually useful to neuroscientists
across a wide range of fields-e.g., neurochemistry,
neuropsychopharmacology, neurology, psychiatry, and neuroanatomy.
Each chapter has been written by well-known neuroscientists with -
tive research programs. Experienced researchers in the specific
areas treated will appreciate the present updates on those topics,
and neuros- entists expecting their research programs to become
more multidisciplinary or to expand into new areas of research
should find these volumes of enormous value, particularly those
sections offering protocols with u- ful hints about the advantages
and potential pitfalls of a particular te- nique.
In Vitro Neurochemical Techniques is one of three volumes that rep-
sent an update of the original Volume 1 of Neuromefkods, General
Neu- chemical Techniques The expansion to three volumes was
necessitated by the rapidly increasing number of techniques being
used by neuroscrentists and the general tendency of neuroscience
research to become more multidisciplrnary and collaborative in
recent years. The two companion volumes are concerned primarily
with In Vwo Neurometkods in one case, and with Cell Neurobiology
Techniques in the other case. Even with three volumes, the coverage
of General Neuvometkods is obviously not exhaustive. We have
attempted to cover those techniques that seem particularly popular
in multidisciplinary neuroscience research. Though some important
techniques may have been omitted, we believe that most of these
have been covered in detail in other recent volumes of Neurometkods
or will be the subjects of upcommg volumes The editors anticipate
that these volumes will prove unusually useful to neuroscientists
across a wide range of fields-e.g., neurochemistry,
neuropsychopharmacology, neurology, psychiatry, and neuroanatomy.
Each chapter has been written by well-known neuroscientists with -
tive research programs. Experienced researchers in the specific
areas treated will appreciate the present updates on those topics,
and neuros- entists expecting their research programs to become
more multidisciplinary or to expand into new areas of research
should find these volumes of enormous value, particularly those
sections offering protocols with u- ful hints about the advantages
and potential pitfalls of a particular te- nique.
The cutting-edge techniques detailed here include those that are
particularly popular in multidisciplinary neuroscience research.
There are readily reproducible methods for establishing neural cell
cultures, measuring enzymes and their inhibitors, and using
quantitative autoradiography to study monoamine uptake sites and
receptors in the brain. Additional methods cover the use of flow
cytometry to study developmental neurobiology, applications of
magnetic resonance spectroscopy (MRS) to human brain metabolism,
and the study of drug metabolism. Together with its companion
volumes, In Vivo Neuromethods and In Vitro Neurochemical
Techniques, all three cutting-edge works will prove exceptionally
useful to those basic and clinical neuroscientists who want to
expand the range of their current research or develop competence in
complementary methods.
A superb collection of time-tested, key techniques for
investigating nervous system function, as well as the actions of
drugs on the nervous system. The methods range from authoritative
treatment of such well-established techniques as recording
electrical activity in the brain, to practical coverage of
state-of-the-art methods, including neural transplantation and
antisense technology. The techniques described are particularly
suitable for studying the mechanisms of action of psychotropic
drugs and drugs of abuse, as well as the etiology and
pharmacotherapy of neuropsychiatric diseases and neurodegenerative
disorders. Several of the methods detailed are highly useful in
screening potential drugs for the treatment of depression, anxiety
disorders, schizophrenia, and Parkinson's and Alzheimer's disease.
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