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Insulin resistance (IR) and metabolic syndrome are associated with
the pathogenesis and progression of non-alcoholic fatty liver
disease (NAFLD). It encompasses a spectrum of hepatic pathology,
ranging from simple steatosis in its most benign form (fatty
liver), going through nonalcoholic steatohepatitis (NASH) in its
intermediate form, until cirrhosis and hepatocellular carcinoma,
its most advanced forms. This book presents current research on the
background of fatty acid oxidation; hepatic steatosis and its
progression to NASH and cirrhosis; fibrosis and myofibroblastic
cells differentiation; methods of diagnosis; clinical features and
laboratory tests and, finally, rodent NAFLD and NASH models.
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