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Dendritic cells are vital to induce potent anti-viral immune responses. It will become clear to the reader that dendritic cells often play a dual role during viral infections. On the one hand they are able to mount potent antiviral immune responses, and on the other hand several viruses, including HIV-1, use DC as a vector to be transferred from the periphery to the lymph nodes where they infect their prime target.
This is the most comprehensive handbook on dendritic cells,
featuring an introduction by Ralph M. Steinman and written by top
experts. In three volumes, it covers all aspects from molecular
cell biology to clinical applications, highlighting the role of
dendritic cells in fighting cancer, virus infections, and
autoimmune diseases.
The first section on cell biology looks at dendritic cell
development, circulating cells, T cell priming, Th1 and Th2
decision and CTL priming. A second part on dendritic cells in
disease deals with parasites, bacteria, viruses, autoimmunity,
allergies, asthma and cancer. The final section on therapeutic
applications includes viral infections and antigen delivery.
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