|
Showing 1 - 4 of
4 matches in All Departments
Topology and Physics of Circular DNA presents comprehensive
coverage of the physical properties of circular DNA. The author
examines how topological constraints arising from cyclization of
DNA lead to distinctive properties that make closed molecules
radically different from linear DNA. The phenomenon of
supercoiling, its geometric and topological analysis, and the
formation of noncanonical structures in circular DNA under the
influence of supercoiling are emphasized. The combination of
consistent theoretical analysis and detailed treatment of major
experimental approaches make Topology and Physics of Circular DNA
an important reference volume for biophysicists, biochemists,
molecular biologists, and researchers and students who want to
expand their understanding of circular DNA.
Topology and Physics of Circular DNA presents comprehensive
coverage of the physical properties of circular DNA. The author
examines how topological constraints arising from cyclization of
DNA lead to distinctive properties that make closed molecules
radically different from linear DNA. The phenomenon of
supercoiling, its geometric and topological analysis, and the
formation of noncanonical structures in circular DNA under the
influence of supercoiling are emphasized. The combination of
consistent theoretical analysis and detailed treatment of major
experimental approaches make Topology and Physics of Circular DNA
an important reference volume for biophysicists, biochemists,
molecular biologists, and researchers and students who want to
expand their understanding of circular DNA.
Accessible and comprehensive, this book describes the universal
cellular nature of living organisms and is an indispensable tool
for anyone in the sciences who wishes to get a quick overview of
molecular biology. Individual chapters cover nucleic acids and
proteins, genetic code and protein synthesis, the fidelity of
transferring genetic information to the next generations, and the
regulation of various processes inside the cells. Special attention
is paid to new areas rising from modern DNA sequencing technologies
which transform biology. The book also touches on developing areas,
such as cures for cancer and CRISPR, which are important for
medicine and the future of humankind.
Surveying the last sixty years of research, this book describes the
physical properties of DNA in the context of its biological
functioning. It is designed to enable both students and researchers
of molecular biology, biochemistry and physics to better understand
the biophysics of DNA, addressing key questions and facilitating
further research. The chapters integrate theoretical and
experimental approaches, emphasising throughout the importance of a
quantitative knowledge of physical properties in building and
analysing models of DNA functioning. For example, the book shows
how the relationship between DNA mechanical properties and the
sequence specificity of DNA-protein binding can be analyzed
quantitatively by using our current knowledge of the physical and
structural properties of DNA. Theoretical models and experimental
methods in the field are critically considered to enable the reader
to engage effectively with the current scientific literature on the
physical properties of DNA.
|
You may like...
Loot
Nadine Gordimer
Paperback
(2)
R398
R330
Discovery Miles 3 300
Hampstead
Diane Keaton, Brendan Gleeson, …
DVD
R66
Discovery Miles 660
Ab Wheel
R209
R149
Discovery Miles 1 490
|