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This detailed volume collects protocols for experimentation into
how neurons connect to produce the extraordinary functionalities of
the nervous system. Contributed by experts and pioneers in their
respective techniques, the book covers synapses in the brain and in
culture, their constituents, their structures, their dynamics, and
the assemblies they form, all in the structure of a laboratory
guide. Written for the highly successful Methods in Molecular
Biology series, chapters include brief introductions to their
respective topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, and tips
on troubleshooting and avoiding known pitfalls. Authoritative and
practical, Synapse Development: Methods and Protocols serves as an
ideal guide to minimizing the barrier to entry for the integration
of new approaches with existing expertise, producing syntheses that
will foster novel perspectives on the many ways in which synapses
form, transform, and transmit.
This detailed volume collects protocols for experimentation into
how neurons connect to produce the extraordinary functionalities of
the nervous system. Contributed by experts and pioneers in their
respective techniques, the book covers synapses in the brain and in
culture, their constituents, their structures, their dynamics, and
the assemblies they form, all in the structure of a laboratory
guide. Written for the highly successful Methods in Molecular
Biology series, chapters include brief introductions to their
respective topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, and tips
on troubleshooting and avoiding known pitfalls. Authoritative and
practical, Synapse Development: Methods and Protocols serves as an
ideal guide to minimizing the barrier to entry for the integration
of new approaches with existing expertise, producing syntheses that
will foster novel perspectives on the many ways in which synapses
form, transform, and transmit.
The establishment of accurate synaptic transmission underlies
neural network processing and nervous system function. The
organized deployment of specialized synaptic machinery is a key
cellular process that shapes the synapse and its transmission
properties, yet the molecular mechanisms involved in assembling the
synaptic apparatus are largely unknown. This work has focused on
the role of Neuroligins, a family of postsynaptic adhesion
molecules, in mediating differentiation of inhibitory, GABAergic
and glycinergic, postsynapses.
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