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Healthcare decision makers in search of reliable information that
compares health interventions increasingly turn to systematic
reviews for the best summary of the evidence. Systematic reviews
identify, select, assess, and synthesize the findings of similar
but separate studies, and can help clarify what is known and not
known about the potential benefits and harms of drugs, devices, and
other healthcare services. Systematic reviews can be helpful for
clinicians who want to integrate research findings into their daily
practices, for patients to make well-informed choices about their
own care, for professional medical societies and other
organizations that develop clinical practice guidelines. Too often
systematic reviews are of uncertain or poor quality. There are no
universally accepted standards for developing systematic reviews
leading to variability in how conflicts of interest and biases are
handled, how evidence is appraised, and the overall scientific
rigor of the process. In Finding What Works in Health Care the
Institute of Medicine (IOM) recommends 21 standards for developing
high-quality systematic reviews of comparative effectiveness
research. The standards address the entire systematic review
process from the initial steps of formulating the topic and
building the review team to producing a detailed final report that
synthesizes what the evidence shows and where knowledge gaps
remain. Finding What Works in Health Care also proposes a framework
for improving the quality of the science underpinning systematic
reviews. This book will serve as a vital resource for both sponsors
and producers of systematic reviews of comparative effectiveness
research. Table of Contents Front Matter Summary 1 Introduction 2
Standards for Initiating a Systematic Review 3 Standards for
Finding and Assessing Individual Studies 4 Standards for
Synthesizing the Body of Evidence 5 Standards for Reporting
Systematic Reviews 6 Improving the Quality of Systematic Reviews:
Discussion, Conclusions, and Recommendations Appendix A:
Abbreviations and Acronyms Appendix B: Glossary Appendix C:
Workshop Agenda and Questions to Panelists Appendix D: Expert
Guidance for Chapter 2: Standards for Initiating a Systematic
Review Appendix E: Expert Guidance for Chapter 3: Standards for
Finding and Assessing Individual Studies Appendix F: Expert
Guidance for Chapter 4: Standards for Synthesizing the Body of
Evidence Appendix G: Expert Guidance for Chapter 5: Standards for
Reporting Systemic Reviews Appendix H: Preferred Reporting Items
for Systematic Reviews and Meta-Analyses (PRISMA) Checklist
Appendix I: Committee Biographies
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