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This book is intended both to be an introduction to techniques and
applications of liquid chromatography/mass spectrometry and to
serve as a reference for future workers. When we undertook its
writing, we chose not to cover the field, particularly
applications, exhaustively. Rather we wished to produce a book that
would be of use to people just beginning to use the technique as
well as to more advanced practitioners. In this regard, we have
sought to highlight techniques and applications that are of current
importance, while not neglecting descriptions of approaches that
may be of significance in the future. We hope that we have
succeeded in this. At the same time we hope that the bibliography,
with indexes classified by author and title, will make this book of
value to those who may disagree with our emphasis. ACKNOWLEDGMENTS.
One of us (C. G. E. ) wishes to acknowledge the en couragment of
Professor J. A. McCloskey in undertaking this project. All four of
us are grateful for the continuous and expert assistance of V. A.
Edmonds in the preparation of the Bibliography. Alfred L. Y ergey
Bethesda, Maryland Charles G. Edmonds Richland, Washington lvor A.
S. Lewis London, England Marvin L. Vestal Houston, Texas v Contents
1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . 1
. . . . . . . . . . . 2. Direct Liquid Introduction Interfaces . .
. . . . . . . . 5 . . . 2. 1. Introduction . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
5 2. 2. Operating Principles . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 7 2. 3. Specific DLI
Interfaces . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . 10 2. 3. 1. Capillary Inlets . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . 10 2. 3. 2.
Diaphragm Interfaces . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . 12 2. 3. 3. Nebulizing Interfaces . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . ."
This book is intended both to be an introduction to techniques and
applications of liquid chromatography/mass spectrometry and to
serve as a reference for future workers. When we undertook its
writing, we chose not to cover the field, particularly
applications, exhaustively. Rather we wished to produce a book that
would be of use to people just beginning to use the technique as
well as to more advanced practitioners. In this regard, we have
sought to highlight techniques and applications that are of current
importance, while not neglecting descriptions of approaches that
may be of significance in the future. We hope that we have
succeeded in this. At the same time we hope that the bibliography,
with indexes classified by author and title, will make this book of
value to those who may disagree with our emphasis. ACKNOWLEDGMENTS.
One of us (C. G. E. ) wishes to acknowledge the en couragment of
Professor J. A. McCloskey in undertaking this project. All four of
us are grateful for the continuous and expert assistance of V. A.
Edmonds in the preparation of the Bibliography. Alfred L. Y ergey
Bethesda, Maryland Charles G. Edmonds Richland, Washington lvor A.
S. Lewis London, England Marvin L. Vestal Houston, Texas v Contents
1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . 1
. . . . . . . . . . . 2. Direct Liquid Introduction Interfaces . .
. . . . . . . . 5 . . . 2. 1. Introduction . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
5 2. 2. Operating Principles . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 7 2. 3. Specific DLI
Interfaces . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . 10 2. 3. 1. Capillary Inlets . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . 10 2. 3. 2.
Diaphragm Interfaces . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . 12 2. 3. 3. Nebulizing Interfaces . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . ."
Volume 9: Historical Perspectives, Part A: The Development of Mass
Spectrometry of The Encyclopedia of Mass Spectrometry describes and
analyzes the development of many aspects of Mass Spectrometry.
Beginning with the earliest types of Mass Analyzers, Historical
Perspectives explores the development of many different forms of
analytical processes and methods. The work follows various
instruments and interfaces, to the current state of detectors and
computerization. It traces the use of Mass Spectrometry across many
different disciplines, including Organic Chemistry, Biochemistry,
and Proteomics; Environmental Mass Spectrometry; Forensic Science;
Imaging; Medical Monitoring and Diagnosis; Earth and Planetary
Sciences; and Nuclear Science. Finally, the book covers the history
of manufacturers and societies as well as the professionals who
form the Mass Spectrometry community. Also available: Volume 9:
Historical Perspectives, Part B: Notable People in Mass
Spectrometry briefly reviews the lives and works of many of the
major people who carried out this development.
Volume 9: Historical Perspectives, Part B: Notable People in Mass
Spectrometry of The Encyclopedia of Mass Spectrometry briefly
reviews the lives and works of many of the major people who carried
out this development, providing insights into the history of mass
spectrometry applications through the personal stories of pioneers
and innovators in the field. The book presents biographies of
notable contributors, including Nobel Prize winners J. J. Thomson,
Francis W. Aston, Wolfgang Paul, John B. Fenn, and Koichi Tanaka,
along with other luminaries in the field, including Franz
Hillenkamp, Catherine Clarke Fenselau, Alfred O. C. Nier, and many
more, discussing not only the instruments and their uses, but also
providing interesting information on the careers, characters, and
life stories of the people who did the work.
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