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Damage to DNA by both exogenous and endogenous sources is
increasingly regarded as highly important in the initiation and
progression of cancer and in the occurance of other pathological
events. DNA damage caused by reactive oxygen-derived species, also
called oxidative DNA damage, is most the frequent type encountered
by aerobic cells. Mechanistic studies of carcinogenesis indicate an
important role of this type of damage to DNA. There is also strong
evidence to support the role of oxidative DNA damage in the aging
process. DNA damage is opposed in vivo by repair systems. If not
repaired, DNA damage may lead to detrimental biological
consequences. Therefore, the repair of DNA damage is regarded as
one of the essential events in all life forms. In recent years the
field of DNA repair has flourished due to new findings on DNA
repair mechanisms and the molecular basis of cancer. A detailed
knowledge of mechanisms of DNA damage and repair, and how
individual repair enzymes function may lead to manipulation of DNA
repair in cells and ultimately to an increase of the resistence of
human cells to DNA-damaging agents. This volume covers the most
recent devlopments in this research field and contains
contributions from scientists working in the fields of
biochemistry, molecular biology, enzymology, biomedical science,
and radiation biology.
Damage to DNA by both exogenous and endogenous sources is
increasingly regarded as highly important in the initiation and
progression of cancer and in the occurance of other pathological
events. DNA damage caused by reactive oxygen-derived species, also
called oxidative DNA damage, is most the frequent type encountered
by aerobic cells. Mechanistic studies of carcinogenesis indicate an
important role of this type of damage to DNA. There is also strong
evidence to support the role of oxidative DNA damage in the aging
process. DNA damage is opposed in vivo by repair systems. If not
repaired, DNA damage may lead to detrimental biological
consequences. Therefore, the repair of DNA damage is regarded as
one of the essential events in all life forms. In recent years the
field of DNA repair has flourished due to new findings on DNA
repair mechanisms and the molecular basis of cancer. A detailed
knowledge of mechanisms of DNA damage and repair, and how
individual repair enzymes function may lead to manipulation of DNA
repair in cells and ultimately to an increase of the resistence of
human cells to DNA-damaging agents. This volume covers the most
recent devlopments in this research field and contains
contributions from scientists working in the fields of
biochemistry, molecular biology, enzymology, biomedical science,
and radiation biology.
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