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Lung Cancer and Imaging (Hardcover)
Ayman El-Baz, Jasjit Suri; Contributions by Ahmed Shaffie, Ahmed Soliman, Ali Mahmoud, …
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R3,442
Discovery Miles 34 420
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Ships in 12 - 17 working days
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1,4-Benzenedicarboxylate(BDC), 1,1'-ferrocenedicarboxylate(FDC) and
their metal complexes are of considerable interest due to their
chemical and biological importance. Thiazoles represent a very
interesting class of compounds because of their pharmaceutical,
analytical and industrial applications. The aim of this work is
therefore to synthesize and characterize a series of transition and
non-transition metal coordination polymers derived from
1,4-benzenedicarboxylate and / or 1,1'-ferrocenedicarboxylate and
thiazoles, to explore their structures and biological activities. A
study of the thermal behaviour of these complexes is important to
elucidate the kinetic and mechanistic aspects of their thermolysis
as well as their stabilities. It is also aimed to study the
voltammetric behaviour of these complexes to gain more
understanding about the chemistry of these compounds.
Methylxanthines especially theophylline have been recognized as
potent bronchodilators for the relief of acute asthma for over 65
years. Recently, it was found that bacterial infection plays a role
in asthma pathogenesis. Accordingly, the present work involves the
synthesis of different series of 8-substituted theophylline
derivatives as novel antiasthmatic candidates with potential
antibacterial activity. A pharmacophore model was constructed to
get useful insight into the essential structural features of
bronchodilator activity. Forty-six of the target compounds were
investigated for in vivo antiasthmatic activity using aminophylline
as a reference standard. Antibacterial activity of all the target
compounds was investigated in vitro against both Gram-positive and
Gram-negative bacterial strains using ampicillin as a reference
standard. Acute toxicity study was also performed. It is noteworthy
to mention that compounds 6c, 8i1, and 14c combined both promising
antiasthmatic and antibacterial activities. These compounds may act
as a corner stone for further investigations by medicinal chemists
in development of new theophylline derivatives for the treatment of
bronchial asthma.
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