1,4-Benzenedicarboxylate(BDC), 1,1'-ferrocenedicarboxylate(FDC) and their metal complexes are of considerable interest due to their chemical and biological importance. Thiazoles represent a very interesting class of compounds because of their pharmaceutical, analytical and industrial applications. The aim of this work is therefore to synthesize and characterize a series of transition and non-transition metal coordination polymers derived from 1,4-benzenedicarboxylate and / or 1,1'-ferrocenedicarboxylate and thiazoles, to explore their structures and biological activities. A study of the thermal behaviour of these complexes is important to elucidate the kinetic and mechanistic aspects of their thermolysis as well as their stabilities. It is also aimed to study the voltammetric behaviour of these complexes to gain more understanding about the chemistry of these compounds.

Methylxanthines especially theophylline have been recognized as potent bronchodilators for the relief of acute asthma for over 65 years. Recently, it was found that bacterial infection plays a role in asthma pathogenesis. Accordingly, the present work involves the synthesis of different series of 8-substituted theophylline derivatives as novel antiasthmatic candidates with potential antibacterial activity. A pharmacophore model was constructed to get useful insight into the essential structural features of bronchodilator activity. Forty-six of the target compounds were investigated for in vivo antiasthmatic activity using aminophylline as a reference standard. Antibacterial activity of all the target compounds was investigated in vitro against both Gram-positive and Gram-negative bacterial strains using ampicillin as a reference standard. Acute toxicity study was also performed. It is noteworthy to mention that compounds 6c, 8i1, and 14c combined both promising antiasthmatic and antibacterial activities. These compounds may act as a corner stone for further investigations by medicinal chemists in development of new theophylline derivatives for the treatment of bronchial asthma.