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The Dietary Reference Intakes (DRIs) are a set of evidence-based
nutrient reference values for intakes that include the full range
of age, gender, and life stage groups in the US and Canada. At the
request of the U.S. Department of Agriculture, Agricultural
Research Service and the U.S. Department of Health and Human
Services, Food and Drug Administration, Center for Food Safety and
Applied Nutrition, the National Academies of Science, Engineering,
and Medicine convened an ad hoc committee to carry out a literature
search and evidence scan of the peer-reviewed published literature
on indicators of nutritional requirements, toxicity, and chronic
disease risk reduction for riboflavin. Scanning for New Evidence on
Riboflavin to Support a Dietary Reference Intake Review builds on
the methodology for evidence scanning nutrients (which have
existing DRIs) to determine whether there is new and relevant
knowledge available that may merit a formal reexamination of DRIs
for riboflavin. This report offers comments on the methodological
approach to the evidence scan and discusses its findings and
interpretation of the process to provide the study sponsors with a
greater context to support their interpretation and application of
the reported results. Table of Contents Front Matter Abstract 1
Introduction 2 Methodological Approach to Evidence Scanning 3
Results 4 Discussion and Future Directions Appendix A: Acronyms and
Abbreviations Appendix B: Open Session Agenda Appendix C:
Literature Searches Appendix D: Committee Member Biographies
Appendix E: Excluded Articles
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