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Drug resistance is a fundamental factor in treatment failure in
diseases like leishmaniasis, although additional factors also play
a role in this phenomenon. This volume is the second edition of a
well-received book that provides a comprehensive update on the
pathology of the disease, as well as on the concept of parasitic
drug resistance, its molecular basis, consequences and possible
treatments. A valuable resource for scientists both from academia
and industry involved in biomedical research and drug design, the
book provides the knowledge needed to understand leishmaniasis and
to contibute to combatting this disease worldwide.
One of the main problems concerning therapeutic tools for the
treatment of parasitic diseases, including leishmaniasis, is that
some field parasites are naturally resistant to the classical
drugs; additionally, current therapies may select parasites prone
to be resistant to the applied drugs. These features are (at least
partially) responsible for the disappointing persistence of the
disease and resultant deaths worldwide. This book provides a
comprehensive view of the pathology of the disease itself, and of
parasitic drug resistance, its molecular basis, consequences and
possible treatments. Scientists both from academic fields and from
the industry involved in biomedical research and drug design, will
find in this book a valuable and fundamental guide that conveys the
knowledge needed to understand and to improve the success in
combating this disease worldwide.
This concise volume describes the latest, up-to-date theory,
methodology, and applications of ABC transporters in
microorganisms. The topics include the structure, physiology, and
evolution of ABC transporters, as well as their special
characteristics in specific microorganisms, including bacteria,
yeast, trypanosomes, and malaria parasites. In particular, the book
describes the most recent research and innovations relative to the
role of ABC transporters in the design of strategies to circumvent
drug resistance in microorganisms. Each chapter comprises an
exhaustive review of the particular topic and provides insights
into the future of the field, both from the scientific and clinical
perspective. A skillful selection of topics and a panel of
acknowledged experts ensure that this concise volume will be of
exceptional importance to everyone involved in DNA superfamily
research, as well as scientists interested in microbial physiology
and multidrug resistance. It is essential reading for anyone
involved in this field, and it is a recommended volume for all
microbiology laboratories.
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