Bipolar disorder is a common, complex and costly mental health disorder, which sits at the heart of the practice of clinical psychiatry.Effective treatments (pharmacological, psychological and brain stimulation based) have all been discovered serendipitously. With the huge advances in basic neuroscience the way is now clear for novel treatments to be developed based on brain science. This book reviews these possibilities.

Bipolar disorder is a common, complex and costly mental health disorder, which sits at the heart of the practice of clinical psychiatry.Effective treatments (pharmacological, psychological and brain stimulation based) have all been discovered serendipitously. With the huge advances in basic neuroscience the way is now clear for novel treatments to be developed based on brain science. This book reviews these possibilities.

Bipolar disorder, or manic depression, is characterised by episodes of pathological mood states. The two poles are mania (with a predominant elated or irritable mood) and depression (with feelings of sadness, anxiety, guilt or hopelessness) but mixed states frequently occur. Episodes can last for many months and profoundly affect physical health, relationships and careers. Since diagnosis and management are difficult, this practical guide provides an overview of the disorder and detailed guidelines for treating the illness throughout its stages, from authors internationally renowned for their work in bipolar disorder. Also discussed are disease theories, mechanisms and key clinical trials, as well as chapters devoted to psychosocial treatments, substance misuse and insights from 'lived experience'. In-depth analyses of selected population groups, including youth, the elderly and women, complement guidelines for clinical approaches in managing bipolar disorder. Comprehensive and detailed, this guide will prove invaluable to clinicians, general practitioners, psychiatrists and psychologists.

Over the past two decades, driven by the enormous public health importance of bipolar disorder, research initiatives have begun to elucidate the pathophysiology of this prevalent and debilitating condition. These research initiatives have led to breakthroughs in our understanding of causation, and now promise to foster the development of novel treatments. This new edition presents contributions from the leaders at the forefront of these areas of research, and includes chapters on the groundbreaking advances in the fields of genetics, neuroimaging, neuropsychopharmacology, oxidative stress and neuronal resilience, inflammatory mechanisms, psychosocial factors, childhood onset and late-life bipolar disorder, and many other important areas. Throughout, the therapeutic implications and potential of this new understanding are emphasized. This will be essential reading for those interested in the neurobiology of mental illness, and will be of interest to mental health practitioners more generally.