Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Asthma is a common chronic respiratory disease that causes substantial morbidity and has been challenging to treat due to its heterogeneous onset, environmental triggers, severity, and treatment response. To update the field on the rapid advances in this field, Precision Approaches to Heterogeneity in Asthma follows its highly successful predecessor, Heterogeneity in Asthma. In this new volume, noted authorities Allan R Brasier and Nizar N Jarjour and a cadre of leaders in the field incorporate new work advancing our understanding of phenotypes (endotypes) of disease, regional variations in ventilation, systems approach to analyzing the findings from studies of inducible phenotypes, and emerging results of biomarker-informed clinical trials. This work will facilitate our current understanding of the spectrum of disease etiology, prognosis, and the likelihood of responding to the range of available therapeutic interventions.

Since the introduction of ciprofloxacin in 1987, fluoroquinolones have expanded far beyond their early role in the treatment of urinary tract infections. Clinical applications beyond genitourinary tract infections include upper and lower respiratory infections, gastrointestinal infections, gynecologic infec- tions, sexually transmitted diseases, and some skin and soft tissue infections. Their ease of administration, favorable pharmacokinetic properties, excellent tolerability, and efficacy give them enormous potential for use and misuse alike. Quinolones have few common adverse effects, most notably nausea, headache and dizziness. Less frequent but more serious adverse events include prolongation of the corrected QT interval, phototoxicity, liver enzyme abnor- malities, arthropathy, and cartilage and tendon abnormalities. While possess- ing many of the favorable properties of intravenous agents, most fluoro- quinolones offer the convenience of oral administration, thus contributing to decreased health-care costs through increased outpatient therapy and short- ened hospital stays. With the recent introduction of agents such as gatifloxacin and moxifloxacin, the traditional Gram-negative coverage of fluoroquinolones has been expanded to include Gram-positive organisms, most importantly Streptococcus pneumoniae.

Organized crime and the mob figures who run it have long captured the imagination of the American public, appearing since the early twentieth century as characters in a host of popular books, movies, and television programs. But often what the public knew of such figures and their criminal careers was as much myth as fact. This book offers highly readable, carefully researched biographies that dispel the the myths but preserve the fascination surrounding 10 infamous New York mob leaders of the twentieth century. Each in-depth biography will help interested readers understand how and why each of these men achieved special notariety within the world of organized crime.

Each biography describes the early years of each man, assessing how he came to a criminal career; his rise to prominence within the mob, providing reaction from those who knew him and witnessed his actions; and the last years of his career, assessing why it ended as it did. Each biography is illustrated with a picture of its subject and concludes with a listing of additional information resources, both print and electronic. A detailed subject index provides further access to the large amount of information contained in each biography. A timeline allows readers to quickly and easily track the birth, death, and important events in the life of each mobster.

Bronchiolitis Obliterans Syndrome in Lung Transplantation presents the most current and up-to-date evidence regarding the diagnosis and management of BOS. In-depth chapters provide readers with a comprehensive understanding of the definition and changing perceptions of the nature of BOS as a clinical and pathologic entity, immune and non-immune mechanisms that have been identified as risk factors for the development of BOS, and interventions that may prove to be clinically useful for the prevention or treatment of BOS. In addition to outlining the current state of knowledge, each chapter provides the reader with the most current and ongoing research in the field as well as identifies areas where future research is needed. Written by an international group of expert authors, Bronchiolitis Obliterans Syndrome in Lung Transplantation is an important new text, that is essential reading for pulmonologists, primary care practitioners, respiratory care practitioners and clinical researchers.

Over the past few decades, the book series Linguistische Arbeiten [Linguistic Studies], comprising over 500 volumes, has made a significant contribution to the development of linguistic theory both in Germany and internationally. The series will continue to deliver new impulses for research and maintain the central insight of linguistics that progress can only be made in acquiring new knowledge about human languages both synchronically and diachronically by closely combining empirical and theoretical analyses. To this end, we invite submission of high-quality linguistic studies from all the central areas of general linguistics and the linguistics of individual languages which address topical questions, discuss new data and advance the development of linguistic theory.

This seventh volume, divided into four parts, addresses the biological determinates of reinforcement and memory. Covers topics in electrical brain stimulation, drugs and reinforcement, and cellular mechanisms.

One of the most crucial but still very poorly understood topics of oceanographic science is the role of ocean processes in contributing to the dynamics of climate and global change. This book presents a series of high level lectures on the major categories of ocean/atmosphere processes. Three of these major issues are the focus of the lectures: (1) air--sea interaction processes; (2) water mass formation, dispersion and mixing; (3) general circulation, with specific emphasis on the thermohaline component. Global examples in the world ocean are provided and discussed in the lectures. In parallel, the Mediterranean Sea is a laboratory basin in providing analogues of the above global processes relevant to climate dynamics. They include the Mediterranean thermohaline circulation with its own conveyor belt'; intermediate and deep water mass formation and transformations, dispersion and mixing. No other book in the field provides a review of fundamental lectures on these processes, coupled with global examples and their Mediterranean analogues.

How do you take talented engineers and surround them with the elements needed to create brilliant designs that lead to market-changing products? Lean 3P is how.
Winner of a 2013 Shingo Research and Professional Publication Award
Written from an operations perspective, The Lean 3P Advantage: A Practitioner s Guide to the Production Preparation Process explains how to build collaborative thinking and innovation into the front end of the design process. Describing how to develop successful new products concurrently with new operations, the book illustrates real-world scenarios with numerous examples and case studies to help newcomers succeed the first time around. For those familiar with 3P, the book supplies the basis to explore Evergreen 3P a process for applying 3P to small-scale design projects for similar benefits.

• Details the 3P Lean Design process, explaining how and why it works so effectively
• Includes case studies and examples of real-world applications
• Presents time-tested methods based on the combined experience of numerous practicing companies

Coverage includes product planning and evaluation criteria, selection of alternatives, timing considerations, construction of prototypes, and measuring effectiveness. This book will help you and your team develop holistic designs that foster innovation and deliver products and production operations that effectively utilize people and exceed the expectations of all stakeholders. "

The argument of this book is two-fold: the target of the argument of Colossians is a Judaism dismissive of the Gentile Colossian Christians and the recognition of that fact casts new light on the moral material of the letter and its integration into the argument of the epistle as a whole.Several arguments are made in support of these claims. Significant parallels between Colossians and Galatians suggest similar concerns in both letters relating to Israel's identity as the people of God and how that relates to the Gentile believers are to live. The writers of Colossians, while sharing a similar Jewish perspective with the Colossian philosophers on the relationship between identity and way of life, admonish the Gentile Christians to live in a way consistent with who they are. Nevertheless Paul and Timothy differ with the philosophers as to what constitutes the identity of the Colossian Gentiles as the people of God. In addition to the parallels drawn further themes are present in Colossians which strongly suggest the Jewish character of the philosophy: wisdom, election, and death of Christ as the final return from exile. The apocalyptic background of 3.1 -6, the Jewish moral concerns of the ethical lists (3.5-17), and the christological orientation of the Haustafel, bolster the claim that the target of Colossians is Jewish in character and the moral material is integral to the argument.

Called "the preeminent survey of American military history" by Russell F. Weigley, America's foremost military historian, "For the Common Defense "is an essential contribution to the field of military history. This carefully researched third edition provides the most complete and current history of United States defense policy and military institutions and the conduct of America's wars. Without diminishing the value of its earlier editions, authors Allan R. Millett, Peter Maslowski, and William B. Feis provide a fresh perspective on the continuing issues that characterize national security policy. They have updated the work with new material covering nearly twenty years of scholarship, including the history of the American military experience in the Balkans and Somalia, analyzing the wars in Iraq and Afghanistan from 2001 to 2012, and providing two new chapters on the Vietnam War.
"For the Common Defense "examines the nation's pluralistic military institutions in both peace and war, the tangled civil-military relations that created the country's commitment to civilian control of the military, the armed forces' increasing nationalization and professionalization, and America's growing reliance on sophisticated technologies spawned by the Industrial Revolution and the Computer and Information Ages. This edition is also a timely reminder that vigilance is indeed the price of liberty but that vigilance has always been--and continues to be--a costly, complex, and contentious undertaking in a world that continually tests America's willingness and ability to provide for the common defense.

Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling. These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response. Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease. An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma. This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma. As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention. "

A sweet romance, where teens make their own summer work. As their business grows, so does their love for one another. A rollercoaster of emotions.

Miriam Hopkins (1902--1972) first captured moviegoers' attention in daring precode films such as Dr. Jekyll and Mr. Hyde (1931), The Story of Temple Drake (1933), and Ernst Lubitsch's Trouble in Paradise (1932). Though she enjoyed popular and critical acclaim in her long career -- receiving an Academy Award nomination for Becky Sharp (1935) and a Golden Globe nomination for The Heiress (1949) -- she is most often remembered for being one of the most difficult actresses of Hollywood's golden age. Whether she was fighting with studio moguls over her roles or feuding with her avowed archrival, Bette Davis, her reputation for temperamental behavior is legendary. In the first comprehensive biography of this colorful performer, Allan R. Ellenberger illuminates Hopkins's fascinating life and legacy. Her freewheeling film career was exceptional in studio-era Hollywood, and she managed to establish herself as a top star at Paramount, RKO, Goldwyn, and Warner Bros. Over the course of five decades, Hopkins appeared in thirty-six films, forty stage plays, and countless radio programs. Later, she emerged as a pioneer of TV drama. Ellenberger also explores Hopkins's private life, including her relationships with such intellectuals as Theodore Dreiser, Dorothy Parker, Gertrude Stein, and Tennessee Williams. Although she was never blacklisted for her suspected Communist leanings, her association with these freethinkers and her involvement with certain political organizations led the FBI to keep a file on her for nearly forty years. This skillful biography treats readers to the intriguing stories and controversies surrounding Hopkins and her career, but also looks beyond her Hollywood persona to explore the star as an uncompromising artist. The result is an entertaining portrait of a brilliant yet underappreciated performer.

Market: Ocean dynamicists and acousticians. "Useful to scientists or students interested in ocean dynamical modelling, acoustic propagation modelling, and particularly to those interested in the union of these fields (which is likely to be become increasingly important)." Revue de livre With complete chapters contributed by leading authorities, this work offers a comprehensive overview of current combined research in acoustics and oceanography. Following an introduction on ocean variability, acoustic propagation, and coupled models, subsequent chapters present up-to-date coverage of the developing relationship between ocean science and ocean acoustics, including an extensive review of state-of-the-art three-dimensional models.