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The present volume contains the edited transcript of a Totts Gap
Colloquium held May 19-21, 1980 sponsored by the Muscular Dystrophy
Association. The aim of the colloquium was to bring into focus data
relating to cell membranes that might contribute to understanding
the pathogenic mechanism of Duchenne muscular dystrophy. A major
impediment to progress in understanding the patho genesis of
muscular dystrophy has been the failure, so far, to identify the
basic genetic defect. Pending the identification of the genetic
lesion in Duchenne dystrophy and, in view of scattered but
persistent indications of a basic membrane disturbance, it seemed
worthwhile to explore in open dialogue the current state of
knowledge of membrane morphology and chemistry with an eye to
possible leads for further investigation. The participants, drawn
from a variety of interested disciplines, attempted to synthesize
and reconcile their findings and to identify crucial areas of
ignorance in need of exploration. For the most part they avoided
specialized jargon and spoke in a language that could be understood
by the rest of the group. Apart from providing a review of widely
varying approaches to the study of the composition and behavior of
cell membranes, the discussions brought together current think g on
strategies and approaches to the study of the pathogenesis of
muscular dystrophy. Already the personal contacts made at the
colloquium have led to new inter-institutional collabora tive
investigations."
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