0
Your cart

Your cart is empty

Browse All Departments
  • All Departments
Price
  • R1,000 - R2,500 (1)
  • R5,000 - R10,000 (1)
  • -
Status
Brand

Showing 1 - 2 of 2 matches in All Departments

G Proteins, Receptors, and Disease (Paperback, Softcover reprint of the original 1st ed. 1998): Allen M. Spiegel G Proteins, Receptors, and Disease (Paperback, Softcover reprint of the original 1st ed. 1998)
Allen M. Spiegel
R1,598 Discovery Miles 15 980 Ships in 10 - 15 working days

"Theoretically, one should obtain essentially the same clinical picture from failure of an end-organ to respond to a hormone as from a decreased production or absence of said hormone. " With these words, Fuller Albright began his now classic paper describing a novel disease, pseudo hypoparathyroidism (PHP), and a novel concept, hormone resis- tance as a cause of disease. Soon, other hormone resistance disorders such as nephrogenic diabetes insipidus (NDI) were recognized, and the concept was extended to resistance to other substances such as calcium ions in familial hypocalciuric hypercalcemia (FHH). Later, diseases characterized by excess rather than deficient hormone action such as McCune-Albright syndrome (MAS) and familial male precocious puberty (FMPP) were recognized to be caused by autonomous endocrine hyperfunction. Although many i!!vestigators provided careful and detailed descriptions of the clinical features of these and other related endocrine disorders, an understanding of pathogenesis proved elusive for many years. In just the past few years, we have gone from clinical description to a molecular understanding of these interesting disorders. This remarkable progress reflects a synthe- sis of three distinct, but now overlapping, areas of biomedical research: the aforemen- tioned recognition and careful clinical description of specific diseases, the elucidation of the basic mechanisms of signal transduction, and the application of the powerful tools of molecular biology and genetics. Fundamental studies on the mechanisms of hormone action by Rodbell and colleagues at NIH culminated in the discovery of a major signal transduction pathway involving heterotrimeric G proteins.

G Proteins, Receptors, and Disease (Hardcover, 1998 ed.): Allen M. Spiegel G Proteins, Receptors, and Disease (Hardcover, 1998 ed.)
Allen M. Spiegel
R6,067 Discovery Miles 60 670 Ships in 10 - 15 working days

"Theoretically, one should obtain essentially the same clinical picture from failure of an end-organ to respond to a hormone as from a decreased production or absence of said hormone. " With these words, Fuller Albright began his now classic paper describing a novel disease, pseudo hypoparathyroidism (PHP), and a novel concept, hormone resis- tance as a cause of disease. Soon, other hormone resistance disorders such as nephrogenic diabetes insipidus (NDI) were recognized, and the concept was extended to resistance to other substances such as calcium ions in familial hypocalciuric hypercalcemia (FHH). Later, diseases characterized by excess rather than deficient hormone action such as McCune-Albright syndrome (MAS) and familial male precocious puberty (FMPP) were recognized to be caused by autonomous endocrine hyperfunction. Although many i!!vestigators provided careful and detailed descriptions of the clinical features of these and other related endocrine disorders, an understanding of pathogenesis proved elusive for many years. In just the past few years, we have gone from clinical description to a molecular understanding of these interesting disorders. This remarkable progress reflects a synthe- sis of three distinct, but now overlapping, areas of biomedical research: the aforemen- tioned recognition and careful clinical description of specific diseases, the elucidation of the basic mechanisms of signal transduction, and the application of the powerful tools of molecular biology and genetics. Fundamental studies on the mechanisms of hormone action by Rodbell and colleagues at NIH culminated in the discovery of a major signal transduction pathway involving heterotrimeric G proteins.

Free Delivery
Pinterest Twitter Facebook Google+
You may like...
First Aid Dressing No 5
R9 Discovery Miles 90
Baby Dove Lotion Night Time
R81 Discovery Miles 810
Faber-Castell Minibox 1 Hole Sharpener…
R10 Discovery Miles 100
MyNotes A5 Rainbow Bands Notebook
Paperback R50 R42 Discovery Miles 420
Handover Round Artist Brush in Pony Hair…
R38 R12 Discovery Miles 120
Bantex @School 13cm Kids Blunt Nose…
R16 Discovery Miles 160
Treeline Tennis Balls (Pack of 3)
R59 R49 Discovery Miles 490
Casio LW-200-7AV Watch with 10-Year…
R999 R884 Discovery Miles 8 840
Monami 401 Tile Grout Coating Marker + 2…
R111 Discovery Miles 1 110
Poltek 1/100 Poultry Infra Red Lamp…
R320 Discovery Miles 3 200

 

Partners