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This book presents an up-to-date and thorough overview of cancer of
unknown primary, encompassing topics ranging from epidemiology,
tumor biology, and prognostic factors through to the most recent
diagnostic and therapeutic advances. All aspects of management are
covered, including radiological, nuclear medicine, and pathological
diagnosis, site-specific therapies, platinum-based combination
chemotherapy, radiotherapy, and novel targeted treatments. Clear
guidance is offered on diagnosis of the tissue of origin by means
of gene expression and micro-RNA analyses and its therapeutic
implications. Detailed directions are also provided on the
identification of subsets of patients with a more favorable
prognosis, in whom specific treatment offers the chance of
long-term survival or even cure. Readers will find Cancer of
Unknown Primary to be an ideal source of practically oriented
information that will assist in delivery of the best possible care
for patients with this challenging diagnosis.
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