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Many extrapyramidal motor diseases result from underlying
neurodegenerative processes, which however are very advanced at the
time the clinical diagnosis is made. From animal experiments it
seems likely that we may soon have several substances that provide
neuroprotective effects, but that their therapeutic use must be as
early as possible. This fact was the starting point for the
meeting, held at Chiemsee, that formed the basis of this book. The
idea was to develop in strumental methods that, first, permit an
earlier diagnosis by drawing on the experience of experts and,
second, provide a better resolution of successful therapy than the
currently used methods. As early as 1886, Charcot tried to
differentiate the tremor of polysclerosis and Parkinson patients by
using a drum developed by Marey, a physiologist. Subse quently,
many apparatuses were developed to better identify movement
disorders, initially for diagnostic purposes. Most of these methods
proved to be inferior to the skill of experienced observers. In the
last two decades, however, both the technical advances made in
measuring methods and the improvements achieved in methods of
evaluation have led to marked advances in the quantification of
motor dis turbances. An objective of the symposium held at Chiemsee
and of this book is to provide an overview of the procedures that
are currently commonly used for extrapyramidal movement disorders,
and to identify their potential and limitations."
A state-of-the-art review of the many cognitive, affective, and
behavioral dysfunctions associated with movement disorders. These
dysfunctions include depression, dementia, psychosis, sleep
disorders arising from Parkinson's and Huntington's disease,
Tourette's syndrome, as well as multiple system atrophy,
progressive supranuclear palsy, corticobasal degeneration, and many
other related disorders. The authors describe these behavioral
syndromes and their neurophysiological and neuropathological
substratum, as well as their diagnostic criteria and therapeutic
guidelines. The cognitive and affective dysfunctions are spelled
out in detail.
Non-motor Parkinson's Disease is a burgeoning area of the movement
disorders field, as patients increasingly live longer and encounter
more late-stage symptoms. The spectrum of non-motor manifestations
spans much of the body, with non-motor features occurring in all
stages of the disease. Identification of symptoms is key for
preserving quality of life and successful treatment. This is a
practical manual on all aspects of pre-motor and non-motor
manifestations of Parkinson's. The genetic causes of non-motor
symptoms are detailed and methods of patient evaluation summarized.
Topics such as autonomic and sexual dysfunction, mood disorders,
and drug-induced symptoms of non-motor Parkinson's are covered in
depth. This is an essential resource for movement disorder
specialists, neurologists and other clinicians involved in caring
for those with Parkinson's disease.
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