The Fourth Edition of Urodynamics Made Easy provides a concise and user-friendly guide to the principles and clinical practice of urodynamics as applied to the routine diagnosis and management of patients. The emphasis of this book is on the ethos behind the practice of urodynamics and how this needs to be integrated into the evaluation of all patients with lower urinary tract symptoms. It offers clear information presented in a visually appealing and easily accessible format. A great and simple teaching tool that will assist the novice as well as the more experienced practitioner Superbly illustrated in full colour. An invaluable and practical, yet comprehensive, resource for all those interested in growing their understanding of and expertise in pelvic floor diseases. This edition has been completely updated, especially in relation to the electronic urodynamic measuring devices now available. The clinical relevance has also been enhanced. Urodynamics made Easy provides an invaluable source of information to urologists, gynaecologists and urodynamic nurses, and will also be of interest to general surgeons, radiologists and general practitioners.

Intellectual property is one of the most valuable assets of an innovative company. By their nature as legal documents, patents can be complicated; and, patenting process can be confusing. Especially entrepreneurs, small companies, and individual inventors are at a disadvantage because of the specialization and resources needed. This book covers the most important topics related to patents and patent applications, gives you a step-by-step roadmap of patent prosecution, and also explains the international patent applications as well as the recent changes that the America Invents Act brought.

Heterobicyclic oxazolo pyrimidinone are important class of compounds. They may become promising candidates for exploiting more useful therapeutically active molecules. The compounds having oxazolo pyrimidinone moiety are associated with interesting wide spectrum biological activities, such as antibacterial, kinase inhibition, adenosine receptor antagonism, tumour growth inhibition and some show to inhibit the ability of ricin to inactivate the ribosomes etc. The intermediate azlactones are also useful precursors for the synthesis of amino acids, peptides, heterocycles, biosensors and antitumor or antimicrobial compounds. In the present study, it was proposed to synthesize lead molecules of oxazolo pyrimidinone skeleton, apt for binding to the target enzyme, bacterial MurB based on the rational approach and to study their docking simulations using ArgusLab 4.0.1 and AutoDock 4.2 softwares. The synthesized test compounds were then characterized by TLC, melting point determination, UV, IR, 1H-NMR and mass spectral studies and tested for their antibacterial activity and compare with the standard drug.

Coumarins are important class of compounds, isomeric to quinolones. They may become promising candidates for exploiting more useful therapeutically active molecules. DNA-gyrase has drawn much attention as selected target for finding potent anti-bacterial agents against multi-drug resistant strains such as methicillin-resistant Staphyloccus aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-resistant Streptococci pneumonia (PRSP). The objective of the present study was, to study the molecular docking simulations on 5,7-dihydroxy-4-methyl coumarin analogues as probable candidates for inhibiting DNA gyrase subunit-B of S.aureus. In the present study, Docking simulations were carried out on the reported inhibitors of DNA-gyrase subunit A and B using docking software. Based on it, Series of 5,7-dihydroxy-4-methylcoumarin analogues (PH-1 to PH-9) were designed, synthesized, characterized and evaluated for its anti-bacterial activity against S.aureus and E.coli. Out of the nine test compounds, compound PH-4 showed good anti-bacterial activity against S.aureus and E.coli than rest of other compounds.