This book provides information and resources to city planners and other public policy officials on the importance of smart sustainable cities and their relationship with urban knowledge-based economy. It answers important topical questions relating to urban sustainable development and human well-being, namely, how can we implement policies and programs that can make cities “smart� and boost their knowledge-based development? How can such programs reduce inequalities and enhance the environment where people live and work? The authors suggest a new approach to the creation of sustainable smart cities, not only in metropolises but also in smaller urban spaces. They advance the body of knowledge in entrepreneurship literature by examining both the European regional understanding of entrepreneurship and the quality of life and well-being at city levels. They also provide synthetic indexes to assess the relationship between perceived quality of life and entrepreneurship.  This book stimulates the debate on the role of smart cities in promoting entrepreneurship, which is a currently under-investigated topic in Europe, and is of interest to a wide range of practitioners, professionals and academics in the area of well-being and quality of life research, urban studies, public policy, and sustainable development.