The Neurobiology of the Gilles de la Tourette Syndrome and Chronic Tics, Volume Three reviews historical background and current nosology and guidelines. In addition, it includes an overview of pathophysiology, ranging from its genetic basis and changes in neurochemistry and electrophysiology to widespread neural circuits. Specific chapters cover Tourette syndrome from phenomenology and natural history to neurobiology, Update and Recent progress in the Neurobiology of Tourette Syndrome, Current guidelines and nosology of Tourette syndrome, Neuroimaging applications in Tourette's Syndrome, Clinical and neurodevelopmental brain imaging of Tourette syndrome, Altered Structural Connectivity in Gilles de la Tourette Syndrome, and much more. The last 20?years have seen an exponential growing body of research dedicated to Gilles de la Tourette Syndrome in the understanding of the syndrome's complex genetics and underlying neurobiology. This unprecedented surge in basic and clinical research has resulted in over 3,000 scientific publications.

The Neurobiology of the Gilles de la Tourette Syndrome and Chronic Tics, Part B, Volume Four reviews historical background, current nosology and guidelines. In addition, it includes an overview of pathophysiology, ranging from its genetic basis and changes in neurochemistry and electrophysiology to widespread neural circuits. Specific chapters cover The genetic basis of Gilles de la Tourette Syndrome, Genome-wide association study of Tourette Syndrome, De Novo mutations in Tourette Syndrome, Animal models for Tourette Syndrome, The neural-immune crosstalk in Tourette syndrome: from immunobiology to epistemology, Functional connectivity in the Gilles de la Tourette Syndrome, and much more.

Antiepileptic drugs are among the most commonly prescribed medications by both neurologists and psychiatrists, as they exert a number of effects which extend far beyond their anticonvulsant properties. There is growing evidence that each antiepileptic drug is characterised by a specific behavioural profile. Behavioural Neurology of Antiepileptic Drugs: A Practical Guide offers a user-friendly guide to the use of antiepileptic drugs and their behavioural effects on patients with epilepsy and primary psychiatric conditions. Written over 18 chapters, this practical handbook guides the reader through the breadth of medications used in modern epilepsy and psychiatry practice alphabetically, including information on each drug's indications, contra-indications, side-effects, and important interactions. This resource covers practical information on prescribing and monitoring to ensure the reader has the most up-to-date evidence-based guidance at their fingertips, and diagrams are used throughout to aid visual learning. With up-to-date content and a practical approach, Behavioural Neurology of Antiepileptic Drugs: A Practical Guide is an invaluable resource for consultants and trainees in neurology, psychiatry, and neuropsychiatry, as well as to pharmacists and specialist epilepsy nurses.

Providing an overview of the assessment, diagnosis, and pharmacological treatment of tics, this is a practical handbook designed for use in busy clinics by trainees and practitioners in a range of disciplines. The most widely used pharmacological treatment options for tics are covered, including first- and second-generation antidopaminergic medications, alpha-2 adrenergic medications, and other tic-suppressing medications. Particular care has been taken in covering the key medications used for tic control, detailing information such as the main pharmacodynamic and pharmacokinetic properties, tolerability profiles, clinically relevant interactions, and recommendations for use in special populations. International guidelines on the pharmacotherapy of tics are defined, with further reading lists of up-to-date literature supporting the reader in developing their knowledge. Delivering evidence-based applied guidance for the assessment and pharmacological treatment of tics, this is an essential manual for clinicians.

The frontal lobes, which constitute about one-third of the entire cerebral cortex, have long fascinated scientific explorers of human behaviour. There are multiple reasons for this: the frontal lobes are the most recently evolved parts of the brain of Homo sapiens and can be viewed as the executive centre of the entire nervous system, subserving the key function of goal-oriented behaviour and reconciling internal emotional states with the demands of the external environment. This book presents some of the latest research on the structure and functional role of the frontal lobes, as revealed by both physiological and pathological studies. This timely and comprehensive volume exemplifies that only a truly multidisciplinary and collaborative effort from the allied disciplines of neuroanatomy, neurophysiology, neuropathology, neuroimaging, neuropsychology and neuropsychiatry will result in a better understanding of the wide-reaching implications of frontal lobe dysfunction.