This volume explores experimental strategies to study progranulin as a regulatory protein in biological and disease processes. The chapters in this book are divided into four parts: Part One is an introduction to the topic; Part Two looks at analytical and in vitro methods to study progranulin biology; Part Three discusses the role of progranulin in cancer; and Part Four describes the process of using animal models to study progranulin in health and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Progranulin: Methods and Protocols is a valuable resource for experienced researchers who want to expand their studies of this field, and newcomers who want to begin including progranulin into their work.

Grounded in a holistic approach, this state-of-the-art workbook provides tools and resources for supporting clients with nonprogressive brain injury. Effective strategies are described for building skills and teaching compensatory strategies in such areas as attention, memory, executive functions, mood, and communication. Particular attention is given to facilitating the challenging process of identity change following a life-altering injury. In a large-size format for easy photocopying, the volume features 93 reproducible client handouts. Purchasers get access to a Web page where they can download and print the reproducible materials.

The aim of neuropsychological rehabilitation is to enable people with cognitive, emotional, or behavioural deficits to achieve their maximum potential in the domains of psychological, social, leisure, vocational or everyday functioning. Describing the holistic programme devised and adopted at the world famous Oliver Zangwill Centre and embracing a broad theoretical base, incorporating a variety of frameworks, theories and models, this book proposes an integrated approach to brain injury rehabilitation by an interdisciplinary team. The coverage explains the underlying principles involved, describes the group therapies employed, highlights a selection of real case examples and reviews the outcomes measured and achieved. This book is essential reading for clinical neuropsychologists, clinical psychologists, speech and language therapists, occupational therapists, psychiatrists, neurologists, physiotherapists, social workers and nurses.