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Biological Mechanisms and the Advancing Approaches to Overcoming
Cancer Drug Resistance, Volume 12, discusses new approaches that
are being undertaken to counteract tumor plasticity, understand and
tackle the interactions with the microenvironment, and disrupt the
rewiring of malignant cells or bypass biological mechanism of
resistance by using targeted radionuclide therapies. This book
provides a unique opportunity to the reader to understand the
fundamental causes of drug resistance and how different approaches
are applied. It is a one-stop-shop to understand why it is so
difficult to treat cancer, and why only a very few patients respond
to therapy and a significant portion develop resistance. Despite a
rapid development of more effective anti-cancer drugs and
combination therapies, cancer remains the leading cause of
lethality in the developed world. The main reason for this is the
ability of heterogeneous subpopulations of tumor cells interacting
with constantly evolving tumor microenvironment to resist
elimination and eventually, trigger cancer relapse. In this book,
experts review current concepts explaining molecular and biological
mechanisms of cancer drug resistance and discussing advancing
approaches for overcoming these therapeutic challenges.
This volume details methods of identifying synthetic lethal,
genetic interactions by various approaches in different model
systems including human cancer cells. Chapters guide readers
through genetic interactions in model organisms, RNA interference,
CRISPR/Cas9 based genome editing technologies, drug-gene
interactions, mapping chemical genetic interactions, synergistic
drug-gene relations, single cell sequencing, gene expression
profiling, and novel genetic interactions. Written in the format of
the highly successful Methods in Molecular Biology series, each
chapter includes an introduction to the topic, lists necessary
materials and reagents, includes tips on troubleshooting and known
pitfalls, and step-by-step, readily reproducible protocols.
Authoritative and cutting-edge, Genetic Interaction Mapping aims to
be a useful practical guide to researches to help further their
study in this field.
This volume details methods of identifying synthetic lethal,
genetic interactions by various approaches in different model
systems including human cancer cells. Chapters guide readers
through genetic interactions in model organisms, RNA interference,
CRISPR/Cas9 based genome editing technologies, drug-gene
interactions, mapping chemical genetic interactions, synergistic
drug-gene relations, single cell sequencing, gene expression
profiling, and novel genetic interactions. Written in the format of
the highly successful Methods in Molecular Biology series, each
chapter includes an introduction to the topic, lists necessary
materials and reagents, includes tips on troubleshooting and known
pitfalls, and step-by-step, readily reproducible protocols.
Authoritative and cutting-edge, Genetic Interaction Mapping aims to
be a useful practical guide to researches to help further their
study in this field.
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