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Nutrients have been recognized as essential for maximum growth,
successful reproduction, and infection prevention since the 1940s;
since that time, the lion's share of nutrient research has focused
on defining their role in these processes. Around 1990, however, a
major shift began in the way that researchers viewed some nutrients
particularly the vitamins. This shift was motivated by the
discovery that modest declines in vitamin nutritional status are
associated with an increased risk of ill-health and disease (such
as neural tube defects, heart disease, and cancer), especially in
those populations or individuals who are genetically predisposed.
In an effort to expand upon this new understanding of nutrient
action, nutritionists are increasingly turning their focus to the
mathematical modeling of nutrient kinetic data. The availability of
suitably-tagged (isotope) nutrients (such as B-carotene, vitamin A,
folate, among others), sensitive analytical methods to trace them
in humans (mass spectrometry and accelerator mass spectrometry),
and powerful software (capable of solving and manipulating
differential equations efficiently and accurately), has allowed
researchers to construct mathematical models aimed at
characterizing the dynamic and kinetic behavior of key nutrients in
vivo in humans at an unparalleled level of detail."
Nutrients have been recognized as essential for maximum growth,
successful reproduction, and infection prevention since the 1940s;
since that time, the lion's share of nutrient research has focused
on defining their role in these processes. Around 1990, however, a
major shift began in the way that researchers viewed some nutrients
particularly the vitamins. This shift was motivated by the
discovery that modest declines in vitamin nutritional status are
associated with an increased risk of ill-health and disease (such
as neural tube defects, heart disease, and cancer), especially in
those populations or individuals who are genetically predisposed.
In an effort to expand upon this new understanding of nutrient
action, nutritionists are increasingly turning their focus to the
mathematical modeling of nutrient kinetic data. The availability of
suitably-tagged (isotope) nutrients (such as B-carotene, vitamin A,
folate, among others), sensitive analytical methods to trace them
in humans (mass spectrometry and accelerator mass spectrometry),
and powerful software (capable of solving and manipulating
differential equations efficiently and accurately), has allowed
researchers to construct mathematical models aimed at
characterizing the dynamic and kinetic behavior of key nutrients in
vivo in humans at an unparalleled level of detail."
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