This book constitutes the proceedings of the 12th International Conference on Internet and Distributed Systems held in Naples, Italy, in October 2019. The 47 revised full papers presented were carefully reviewed and selected from 145 submissions. This conference desires to look for inspiration in diverse areas (e.g. infrastructure & system design, software development, big data, control theory, artificial intelligence, IoT, self-adaptation, emerging models, paradigms, applications and technologies related to Internet-based distributed systems) to develop new ways to design and manage such complex and adaptive computation resources.

This book constitutes the thoroughly refereed post-conference proceedings of the 15th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics., CIBB 2018, held in Caparica, Portugal, in September 2018. The 32 revised full papers were carefully reviewed and selected from 51 submissions. The papers present current trends at the edge of computer and life sciences, the application of computational intelligence to a system and synthetic biology and the consequent impact on innovative medicine were presented. Theoretical and experimental biologists also presented novel challenges and fostered multidisciplinary collaboration aiming to blend theory and practice, where the founding theories of the techniques used for modelling and analyzing biological systems are investigated and used for practical applications and the supporting technologies.