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During the past decade there has been a dramatic expansion of our
knowledge on phospholipases in general, and phospholipase A2 (PLA2)
in particular. Progress in this field has been evident on many
fronts, with novel information rapidly accumulating in the
literature regarding the chemistry and molecular biology of this
enzyme and its role in many important physiological processes.
These include cellular signal transduction via the G-protein cycle,
and in the generation of many cellular mediators, such as the
platelet activating factor (PAF) and the eicosanoids that
participate in the initiation and propagation of inflammation, to
mention a few. This symposium was organized to obtain an overview
of current investigations on this enzyme from the standpoint of its
chemistry, molecular biology and physiology. Another important
focus of this symposium concerns the regulation of PLA2, including
endogenous and synthetic inhibitors and activators of this enzyme.
To review these important areas in PLA2 research we invited
scientists who made significant contributions in this field. The
papers in this volume are organized to emphasize the recent
advances in several areas of investigation, including: (I) the
structure and mechanism of action of PLA2, (2) mechanism of
activation of PLA2, (3) molecular biology, physiology and
endogenous inhibitors of this enzyme and finally, (4) clinical
investigations emphasizing the pathophysiological role of this
enzyme in human diseases. The first article in this volume is by
Dr.
During the past decade there has been a dramatic expansion of our
knowledge on phospholipases in general, and phospholipase A2 (PLA2)
in particular. Progress in this field has been evident on many
fronts, with novel information rapidly accumulating in the
literature regarding the chemistry and molecular biology of this
enzyme and its role in many important physiological processes.
These include cellular signal transduction via the G-protein cycle,
and in the generation of many cellular mediators, such as the
platelet activating factor (PAF) and the eicosanoids that
participate in the initiation and propagation of inflammation, to
mention a few. This symposium was organized to obtain an overview
of current investigations on this enzyme from the standpoint of its
chemistry, molecular biology and physiology. Another important
focus of this symposium concerns the regulation of PLA2, including
endogenous and synthetic inhibitors and activators of this enzyme.
To review these important areas in PLA2 research we invited
scientists who made significant contributions in this field. The
papers in this volume are organized to emphasize the recent
advances in several areas of investigation, including: (I) the
structure and mechanism of action of PLA2, (2) mechanism of
activation of PLA2, (3) molecular biology, physiology and
endogenous inhibitors of this enzyme and finally, (4) clinical
investigations emphasizing the pathophysiological role of this
enzyme in human diseases. The first article in this volume is by
Dr.
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