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Stereology is a valuable tool for neuroscientists, allowing them to
obtain 3-Dimensional information from 2-Dimensional measurements
made on appropriately sampled sections (usually obtained from
histological sections or MRI/CT/PET scans). This 3-D information is
invaluable in correlating
structural/functional relationships in the pursuit of far greater
understanding of the function of the central nervous system.
However, in carrying out such measurements, often based on limited
data sets, there is a risk of experimenter bias. An important
feature of modern design based stereology is
to be aware of potential sources of bias and eliminate them during
the data collection. With many of the major neuroscience journals
now insisting that quantitative data be presented, there is a
greater need than ever for neuroscientists to understand the theory
and practice behind quantitative
methods, such as those offered by stereology. Quantitive Methods in
Neuroscience is a cookbook of stereological methods written
especially for neuroscientists. It provides clear and accessible
advice about when and when not to use stereology. Throughout the
book, the emphasis is on practical
guidance, rather than discussions and formulae. Written by leading
scientists in the field of stereology, with a Foreword by D.C.
Sterio, the book will be a valuable introduction to these methods
for neuroscientists, and all those involved in development of new
drug programmes.
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