Nearly half of all undergraduate students enroll in a two-year college, and many STEM students take their introductory chemistry courses at a two-year college. The educational pathway of these students is often complex and nonlinear towards completion of a certificate, degree and/or transfer to a four-year program. These non-traditional pathways present distinct challenges in and out of the classroom for the educators who are trying to serve this important and diverse group of students. This book provides some insight into the current state of chemistry education reform at two-year colleges, provides specific ways to address some of the challenges of educating two-year college students, and reports strategies for success in chemistry at the two-year college. The contributing authors are chemical educators who have presented at one or more of our Strategies Promoting Success of Two-year College Students symposia that have been held at the Spring ACS National meetings since 2015.