The health and economic devastation caused by COVID-19 has revealed that most countries’ national health systems are inadequate to cope with pandemics. These are global challenges that call for global responses. At the heart of this book is a bold new proposal to create a global pandemic playbook that can be quickly deployed when the next pandemic strikes. Countries and their experts must collaborate to create early warning systems, preparedness, prevention, responses and containment. But who should pay the cost? Anne Kabagambe, a former Executive Board director for the World Bank Group, explores the options, and argues that to fail to learn from COVID-19 and neglect to create a global playbook now would cost far more when the next pandemic strikes.