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Neuro-Urology Research: A Comprehensive Overview describes the
current status of the neuro-urology field, discusses potential
future directions and explains the latest neuroscience tools that
can be used in neuro-urology research. The first section provides
an overview of the circuit-based interrogation of subcortical and
spinal networks involved in bladder filling and voiding. The second
section discusses the translational potential of research for
patients including specific chapters on the sensation of bladder
stretch, bladder pain, the effects of hormones and the potential
results of neurodegeneration on bladder function. The third section
compares traditional and current studies determining the need for
addressing or readdressing principles or adjusting dogma. Section
four introduces techniques including optogenetic manipulation and
calcium imaging of neural activity, and on how these methods can be
applied to neuro-urology research. The fifth and final section
proposes studies in directions that have remained underexplored or
otherwise controversial. Perfect for all currently researching
neuro-urology, this detailed understanding of the cellular and
synaptic circuits that control bladder filling and voiding and of
the circuitry regulating bladder function, has the potential to
inform the development of newer therapeutics for treating LUTS.
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